P477Myeloid PHD-2 deficiency leads to enlarged and fibrotic atherosclerotic plaques in mice
Article 2014 en
Authors
TT
Thomas Theelen
EM
Elke Marsch
JD
Jasper A. F. Demandt
Abstract
1 min read
Purpose: Macrophage specific knockout of PHD-2 prolylhydroxylase domain protein 2 (PHD-2-/-), the crucial cellular oxygen sensor, increased anti-inflammatory M2 macrophages, angiogenesis and arteriogenesis in mice. As macrophages and angiogenesis are known to enhance progression of atherosclerotic plaques, we hypothesized that macrophage PHD-2-/- would increase plaque size and progression.
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