No abstract is provided for this article.
No abstract is provided for this article.
The gastrointestinal (GI) tract's primary role is food digestion, relying on coordinated fluid secretion and bowel movements triggered by mechanosensation. Enteroendocrine cells (EECs) are specialized mechanosensitive cells that convert mechanical forces into electrochemical signals, culminating in serotonin release to regulate GI motility. Despite their pivotal role, knowledge of EEC mechanical properties has been lacking due to their rarity and limited accessibility. In this brief report, we present the first single-cell mechanical characterization of human ECCs isolated from healthy intestinal organoids. Using single-cell optical tweezers, we measured EEC stiffness profiles at the physiological temperature and investigated changes following tryptophan metabolism inhibition. Our findings not only shed light on EEC mechanics but also highlight the potential of adult stem cell-derived organoids for studying these elusive cells.
No abstract is provided for this article.
Building on conservation of resources theory and the dynamic equilibrium model, this three‐wave longitudinal study among 260 Dutch agricultural business owners (1‐year time intervals) investigated reciprocal relationships between the financial situation of the business and psychological distress. Results of structural equation modelling analyses revealed a negative spiral of farm decline, in which psychological variables played a key role. Experiencing financial problems predicted psychological distress, and acted as a self‐fulfilling prophecy by strengthening intentions to quit the business, which predicted a deterioration of the objective financial situation of the business 1 year later. Moreover, farmers experiencing more psychological distress were more likely to get caught in this negative spiral than business owners with better mental health, because they experienced more financial problems, irrespective of their objective financial situation. Long‐term psychological distress rather than temporary fluctuations in distress levels accounted for this effect.
While the academic literature acknowledges that workaholism may result from individual characteristics as well as from environmental factors, little is known about the joint impact of these two kinds of antecedents. The present study explores whether the interaction between the perception of an overwork climate in the workplace and person characteristics (i.e., achievement motivation, perfectionism, conscientiousness, self-efficacy) may foster workaholism. Data were collected on a sample of 333 Dutch employees. The results of moderated regression analyses fully supported our hypotheses and showed that the interaction between an overwork climate and person characteristics is related to workaholism. More specifically, our results revealed a significant increase in workaholism when employees both possessed person characteristics that predispose them toward workaholism and perceived an overwork climate in their workplaces. In addition, conscientiousness and self-efficacy were related to workaholism, but only in interaction with the presence of an overwork climate. These results contribute to the ongoing conceptualization of workaholism by demonstrating empirically that a work environment characterized by an overwork climate may foster workaholism, especially for those high in achievement motivation, perfectionism, conscientiousness, and self-efficacy.
No abstract is provided for this article.
