The inaugural FASEB Science Research Conference (SRC) on Cellular Plasticity in Cancer was held in May 2025 in Hong Kong SAR, China. This event brought together leading experts to discuss cutting-edge research centered on cancer cell plasticity. The conference featured comprehensive presentations covering a broad spectrum of topics, including oncofetal reprogramming in tumor development and progression, mechanisms regulating cancer cell plasticity, metabolic reprogramming and its role in tumor progression, cancer cell plasticity during metastasis, cancer stem cell programs within the tumor microenvironment, tumor plasticity and immune evasion, as well as innovative therapeutic strategies aimed at targeting stem cell-like states, modulating cancer cell states, and effectively controlling disease progression. It is anticipated that the insights gained from this meeting will catalyze further advancements in cancer biology and therapy.
By using a full panel design in a representative sample of Finnish dentists (N=2555), the present study aimed to test longitudinally the motivational and health impairment processes as proposed in the Job Demands-Resources (JD-R) model. The second aim was to investigate whether home resources and home demands have an additional influence on both processes over time. The hypotheses were tested with cross-lagged analyses based on two waves over a three-year period. The results supported both the motivational process and the health impairment process. Job resources influenced future work engagement, which, in turn, predicted organizational commitment, whereas job demands predicted burnout over time, which, in turn, predicted future depression. In addition, job resources had a weak negative impact on burnout. Home demands and home resources did not influence the motivational or health impairment process over time. The results support the central role of work characteristics for health and well-being. By integrating both human thriving and ill-health in the same model, the JD-R model may help to bridge the gap between "negative" and "positive" psychology.
No abstract is provided for this article.
. Virtually all studies on workaholism and engagement – two forms of heavy work investment – rely on self-part questionnaires. However, the limitations of self-reports are widely acknowledged and in their final sections, papers on workaholism and engagement typically lament the use of such measures. Investigating data other than respondents’ self-reports, such as peer ratings, may overcome these limitations. Using a sample of 73 dyads composed of focal workers and their colleagues, the present study aimed: (1) to compare focal workers’ and coworkers’ perceptions concerning their levels of work engagement and workaholism; and (2) to explore the discriminant validity of engagement and workaholism. A multitrait-multimethod (MTMM) matrix and a correlated trait-correlated method model, the CT-C(M-1) model, were examined. Our results showed a considerable agreement between both raters (i.e., focal workers and coworkers) in levels of engagement and workaholism. In contrast to previous findings, a significant difference between raters on the cognitive dimension of workaholism (i.e., working compulsively) was observed. Moreover, our results provided further evidence for the discriminant validity between the two forms of heavy work investment.
No abstract is provided for this article.
The reliability and validity of the Effort-Reward Imbalance Questionnaire were tested in 775 blue- and white-collar workers in the Netherlands. Cronbach's alpha revealed sufficient internal consistency of all subscales except Need for Control. With exploratory probabilistic scaling (Mokken) analysis, the psychometric qualities of the Need for Control scale were improved. With confirmatory factor analysis, the factorial validity of the Extrinsic Effort and Reward subscales was confirmed. A model with 3 separate dimensions for reward (status control, esteem reward, and monetary gratification) proved adequate, emphasizing the importance of distinguishing subscales. The congruent validity of the subscales and a hypothesized relationship with an external construct, health functioning, were confirmed.
No abstract is provided for this article.
This conclusion presents some closing thoughts on the concepts covered in the preceding chapters of the book. The book demonstrates that burnout has been placed successfully on the academic agenda. It seems to be a concept that can guide serious theoretical as well as empirical investigation. Moreover, the burnout concept appears to be a fruitful extension and deepening of the traditional occupational stress research area. The book focuses on three levels of conceptual integration. First, burnout is considered from four general psychological perspectives. Second, in a number of contributions, burnout is linked somewhat more eclectically with elements from several theoretical approaches. Finally, several authors offer a description of a model of burnout that is based mainly on the outcomes of their empirical research, that is, Maslach's multidimensional perspective, Golembiewski's phase model, and Leiter's process model.
<title>Abstract</title> This protocol outlines reagents and procedures to generate human knock-in organoids using our established strategy named CRISPR-HOT. The protocol describes the plasmids to be used and strategies to generate knock-in organoids from different organs.
