Publications

Supplementary Figure S5 from Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

<p>Immune cell landscape of Ewing sarcoma</p>

A multilevel study on servant leadership, job boredom and job crafting

Purpose The purpose of this paper is to examine cross-level effects of team-level servant leadership on job boredom and the mediating role of job crafting. Cross-level moderating effects of team-level servant leadership were also investigated. Design/methodology/approach This longitudinal study employed a multilevel design in a sample of 237 employees, clustered into 47 teams. Servant leadership was aggregated to the team-level to examine the effects of shared perceptions of leadership at T1 on individual-level outcome, namely job boredom, at T2. In addition, mediation analysis was used to test whether team-level servant leadership at T1 can protect followers from job boredom at T2 by fostering job crafting at T2. Cross-level moderating effects of team-level servant leadership at T1 on the relation between job crafting at T2 and job boredom at T2 were also modeled. Findings Job crafting at T2 mediated the cross-level effect of team-level servant leadership at T1 on job boredom at T2. Research limitations/implications The findings suggest that team-level servant leadership predicts less job boredom by boosting job crafting. Originality/value This study is the first to assess the effects of servant leadership on job boredom and the mediating role of job crafting. This paper examines job boredom in a multilevel design, thus extending knowledge on its contextual components.

Movie S2 from Oral Mucosal Organoids as a Potential Platform for Personalized Cancer Therapy

<p>Movie S2</p>

Psychosocial work characteristics and long-term sickness absence due to mental disorders

Background: Psychosocial work characteristics are associated with all-cause long-term sickness absence (LTSA).Aims: This study investigated whether psychosocial work characteristics such as higher workload, faster pace of work, less variety in work, lack of performance feedback, and lack of supervisor support are prospectively associated with higher LTSA due to mental disorders.Methods: Cohort study including 4877 workers employed in the distribution and transport sector in The Netherlands. Psychosocial work characteristics were included in a logistic regression model estimating the odds ratios (OR) and 95% confidence intervals (CI) of mental LTSA during 2-year follow-up. The ability of the regression model to discriminate between workers with and without mental LTSA was investigated with the area under the receiver operating characteristic curve (AUC).Results: Tow thousand seven hundred and eighty-two (57%) workers were included in the analysis; 73 (3%) had mental LTSA. Feedback about one’s performance (OR = 0.82; 95% CI 0.70–0.96) was associated with mental LTSA. A prediction model including psychosocial work characteristics poorly discriminated (AUC = 0.65; 95% CI 0.56–0.74) between workers with and without mental LTSA.Conclusions: Feedback about one’s performance is associated with lower rates of mental LTSA, but it is not useful to measure psychosocial work characteristics to identify workers at risk of mental LTSA.

Sca-1 expression level identifies quiescent hematopoietic stem and progenitor cells

Psychological meaning during organizational change: Development and validation of the Meaning-Making Scale

No abstract is provided for this article.

A comprehensive transcriptome characterization of individual nuclear receptor pathways in the human small intestine

Nuclear receptors (NRs) are widely expressed transcription factors that bind small, lipophilic compounds and regulate diverse biological processes. In the small intestine, NRs are known to act as sensors that control transcriptional responses to endogenous and exogenous signals, yet their downstream effects have not been characterized extensively. Here, we investigate the activation of six different NRs individually in human intestinal organoids using small molecules agonists. We observe changes in key enterocyte functions such as lipid, glucose, and amino acid absorption, the regulation of electrolyte balance, and drug metabolism. Our findings reinforce PXR, LXR, FXR, and PPARα as regulators of lipid absorption. Furthermore, known hepatic effects of AHR and VDR activation were recapitulated in the human small intestine. Finally, we identify unique target genes for intestinal PXR activation (ERG28, TMEM97, and TM7SF2), LXR activation (RAB6B), and VDR activation (CA12). This study provides an unbiased and comprehensive transcriptomic description of individual NR pathways in the human small intestine. By gaining a deeper understanding of the effects of individual NRs, we might better harness their pharmacological and therapeutic potential.

Extended Methods from Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

<p>Extension of the methods related to the scRNA-seq data analysis</p>

Stem cells in veterinary medicine

Supplementary Figure S4 from Ewing Sarcoma Single-cell Transcriptome Analysis Reveals Functionally Impaired Antigen-presenting Cells

<p>Characterisation of Ewing sarcoma tumor cell clusters</p>

In Search Of Theory: Some Ruminations on the Nature And Etiology of Burnout

Reading the theoretical literature on the burnout syndrome for the past decade, one sometimes gets the impression that what is being looked for is a specific cause of a specific mental disorder. If it has a name, we will find what lies behind it—something akin to a metabolic deficiency or a virus. Could it be role conflict, lack of feedback, an external locus of control, or too much red tape? Correlations between these and burnout measures keep being significant, given adequate sample sizes, but not very impressive numerically. And so the search goes on.

All day and all of the night: The relative contribution of two dimensions of workaholism to well-being in self-employed workers

This study examined the associations between workaholism and perceived health (exhaustion, physical complaints, and feelings of professional efficacy) in a sample of 477 Dutch self-employed workers. We defined workaholism as having two components: (1) spending many hours on one's work, and (2) the inability to detach from work. We expected that both workaholism components would be related to ill health. ANOVA and regression analyses revealed that this reasoning was confirmed for one component (inability to detach from work), whereas the other component (working long hours) was unrelated to the outcome variables. In order to increase understanding of these findings, we suggest that more theoretical work be conducted on the mechanisms linking workaholism to its presumed antecedents and consequences. Keywords: Workaholismself-employedentrepreneurseffort expenditurewell-beingburnoutworking hourswork-related stress

Ethnic diversity at work

No abstract is provided for this article.

Evidências de validade da versão brasileira da escala de workaholism (DUWAS-16) e sua versão breve (DUWAS-10)

RESUMOO workaholism caracteriza-se por um estado mental em que os profissionais trabalham excessiva e compulsivamente.Este estudo objetivou avaliar as propriedades psicométricas das versões extensa (DUWAS-16) e reduzida (DUWAS-10) da Dutch Work Addiction Scale (DUWAS) para o contexto brasileiro.Participaram da pesquisa 571 trabalhadores (65,5% do sexo feminino) com idade média de 36,4 anos (DP = 10,8).A análise fatorial confirmatória (AFC) da DUWAS-16 evidenciou que a escala pode ser utilizada adotando uma estrutura de dois fatores oblíquos (Trabalhar Excessivamente e Trabalhar Compulsivamente) ou uma estrutura unidimensional (Adição).A AFC da versão reduzida DUWAS-10 sugere que tanto a estrutura unidimensional (Adição) ou de dois fatores oblíquos (Trabalhar Excessivamente e Trabalhar Compulsivamente) são adequadas.Os resultados indicaram que a DUWAS-10 pode ser considerada superior a DUWAS-16 para avaliar as dimensões de workaholism no contexto brasileiro.

Diabetes, employment and fatigue-related complaints: A comparison between diabetic employees, 'healthy employees and employees with other chronic diseases'

The work situation and fatigue-related complaints of employees with diabetes (N = 141) were compared with healthy employees (N = 8946) and employees with other chronic diseases (N = 1883). Baseline data from a Dutch Cohort Study on Fatigue at Work were used to test differences in background variables, work characteristics, lifestyle factors, and fatigue-related complaints. Odds ratios were calculated for prolonged fatigue, the need for recovery, burnout, and psychological distress. Results showed that employees with diabetes work more daytime hours and work less overtime than the other groups. If they have no comorbidity, they are no more likely to report fatigue-related complaints than healthy employees, except for a depressed mood. Comorbidity (the presence of one or more additional chronic diseases) is associated with increased fatigue-related complaints. Therefore, this group will need special attention from professionals.

Intestinal organoid cocultures with microbes

Work and organizational psychology in hospitals

(1996). Work and organizational psychology in hospitals. Work & Stress: Vol. 10, No. 3, pp. 193-194.

De Euricus-projecten

No abstract is provided for this article.