Plasmodium vivax malaria is characterized by relapses arising from the hypnozoite stages in the liver. The only currently registered drug for radical treatment to prevent relapse is primaquine. Primaquine, a prodrug, requires metabolism through the liver cytochrome CYP2D6 isoenzyme to its active metabolite. Mutations in the CYP2D6 gene may thus affect primaquine efficacy. A SNPs genotyping technique was developed to characterize the CYP2D6 genetic variants and tested this in the patients with Plasmodium vivax infection collected in a Karen population on the Thailand-Myanmar border, where P. vivax malaria is endemic.
Individual variation in growth rates often generates variation in fitness. However, the ability to draw meaningful inferences from growth data depends on the use of growth models that allow for direct comparisons of growth between the sexes, between populations, and between species. Unlike traditional sigmoid functions, a recently parameterized family of unified growth models provides a reliable basis for comparisons since each parameter affects a single curve characteristic and parameters are directly comparable across the unified family. Here, we use the unified-models approach to examine the development of sexual size dimorphism in Damaraland mole-rats (Fukomys damarensis), where breeding males are larger than breeding females. Using skeletal measurements, we show here that the larger size of male Damaraland mole-rats arises from an increased growth rate across the entire period of development, rather than through sex differences in the duration or timing of growth. Male-biased skeletal size dimorphism is not unusual among rodents, and our measures of sex differences in size in captive mole-rats are close to sexual size differences in the wild, where size dimorphism = 1.04 (male:female). We hope our study will encourage the wide use of unified growth models by mammalogists.
No abstract is provided for this article.
Despite impressive growth in the early twenty-first century, Indonesia’s economic performance in the post-colonial era lagged behind that of its neighbours in Malaysia and Singapore. The different development paths chosen, particularly in the treatment of foreign (and, especially, ex-colonial) investment, were central to this—Indonesia’s rejection of Western capital in the 1950s and 1960s, and continued suspicion of foreign economic influence in the 1970s, contrasted with the more open approach of Malaysia and Singapore. How the post-colonial foreign presence was dealt with was largely conditioned by how decolonization was settled—the restrictive agreements reached between Indonesia and the Netherlands, and ongoing Dutch occupation of Irian Jaya, were sources of widespread resentment, and differed significantly from the more liberal approach of the British towards Malaysian and Singaporean independence. The short-term settlement of decolonization was therefore of greater significance than the longer-term nature of colonial rule in determining post-colonial economic patterns.
