Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria — Cindy S. Chu (2018) | RDL Network
Comparison of the Cumulative Efficacy and Safety of Chloroquine, Artesunate, and Chloroquine-Primaquine in Plasmodium vivax Malaria
Clinical Infectious Diseases 67(10): 1543-1549
Article 2018 English
Authors
CC
Cindy S. Chu
AP
Aung Pyae Phyo
KL
Khin Maung Lwin
Abstract
1 min read
Chloroquine has been recommended for Plasmodium vivax infections for >60 years, but resistance is increasing. To guide future therapies, the cumulative benefits of using slowly eliminated (chloroquine) vs rapidly eliminated (artesunate) antimalarials, and the risks and benefits of adding radical cure (primaquine) were assessed in a 3-way randomized comparison conducted on the Thailand-Myanmar border.
Cindy S. Chu, Aung Pyae Phyo, Claudia Turner, Htun Htun Win, Naw Pet Poe, Widi Yotyingaphiram, Suradet Thinraow, Pornpimon Wilairisak, Rattanaporn Raksapraidee, Verena I. Carrara, Moo Kho Paw, Jacher Wiladphaingern, Stéphane Proux, Germana Bancone, Kanlaya Sriprawat, Sue J. Lee, Atthanee Jeeyapant, James A Watson, Joel Tärning, Mallika Imwong, François Nosten, Sir Nicholas White
Victor Chaumeau, Praphan Wasisakun, James A Watson, Thidar Oo, Sarang Aryalamloed, Mu Phang Sue, Gay Nay Htoo, Naw Moo Tha, Laypaw Archusuksan, Sunisa Sawasdichai, Gornpan Gornsawun, Somya Mehra, Sir Nicholas White, François Nosten
Victor Chaumeau, Praphan Wasisakun, James A Watson, Thidar Oo, Sarang Aryalamloed, Mu Phang Sue, Gay Nay Htoo, Naw Moo Tha, Laypaw Archusuksan, Sunisa Sawasdichai, Gornpan Gornsawun, Somya Mehra, Sir Nicholas White, François Nosten
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