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Abstract Response spectra and spectrum intensity for the vertical component of strong motions recorded at El Centro (1940), Olympia (1949) and Taft (1952) are evaluated. Comparison with results for horizontal ground motion components indicates: ( 1 ) spectrum intensity of vertical components is about 20 to 30 per cent of that for horizontal components, and ( 2 ) spectra for vertical components are relatively accentuated in the shorter-period range and reduced in the longer-period range. Results of analysis of a typical earth dam cross-section subjected separately to two (N69W and vertical) components of Taft ground motion are presented. The two dimensional stress analysis technique used is based on the finite element concept. The significance of response to vertical ground motion is discussed. It is concluded that effects of vertical component of ground motion are large enough to warrant consideration for this class of structures.

The National Study of Physician Organizations and the Management of Chronic Illness (NSPO) was designed to improve understanding of evidence-based care management processes (CMPs) as they relate to physician organizations (POs), that is, independent practice associations (IPAs) and medical groups. Since the first NSPO survey of physician organizations in 2000-2001 (NSPO1, archived as ICPSR 4455), considerable investments have been made by a number of different sources, including the Robert Wood Johnson Foundation, the California Healthcare Foundation, and The Commonwealth Fund, to bring about improved care for the chronically ill. This survey, the second NSPO survey of IPAs and medical groups (NSPO2), examined the extent to which the investments in quality improvement were translated into action. NSPO2 assessed the status of CMPs and preventive services use as well as their key drivers in 2006-2007 and the extent to which these factors have changed over time. As in the first NSPO survey, NSPO2 focused on the treatment of four chronic diseases: asthma, congestive heart failure (CHF), depression, and diabetes. Topics covered by the survey include practice type, size, age, ownership, and number of locations; clinical information systems; care management and clinical practice; activities of health insurance plans in chronic illness care; performance incentives; preventative care and health promotion; and organizational culture. This collection has two data files. The first file contains the NSPO2 survey data, while the second contains a crosswalk between the NSPO1 and NSPO2 case identification numbers which can be used to link the data of the POs that responded to both surveys. Altogether, 369 of the 1,104 POs that responded to NSPO1 also responded to NSPO2.

The addition of an N-H bond to an olefin is the most direct route for the synthesis of alkylamines. Currently, intermolecular hydroamination is limited to reactions of a narrow range of reagents containing N-H bonds or activated alkenes, and all the examples of additions to unactivated alkenes require large excesses of alkene. We report intermolecular hydroamination reactions of indoles with unactivated olefins. The reactions occur with as few as 1.5 equiv of olefin to form N-alkylindoles exclusively and in good yield. Characterizations of the catalyst resting state, kinetic data, labeling studies, and computational data imply that the addition occurs by olefin insertion into the Ir-N bond of an N-indolyl complex and that this insertion reaction is faster than insertion of olefin into the Ir-C bond of the isomeric C-2-indolyl complex.

In an era of shifting the energy paradigm from fossil fuels to renewable energy, CO 2 reduction reaction (CO 2 RR) emerges as a promising approach to covert greenhouse gas into valuable chemical fuels and close the carbon cycle for a sustainable energy supply. Since Cu remains the sole element for CO 2 RR to multicarbon products (C 2+ ), significant efforts have been devoted to developing Cu electrocatalysts with higher selectivity and activity. However, the complex nature of active sites and the intrinsic structures under reaction conditions have remained largely elusive due to the lack of operando / in situ methods. 1-3 In our previous studies, we reported that small Cu nanoparticles (sub-10 nm NPs) showed superior C 2+ superior C 2+ selectivity, relative to the larger sized Cu NPs, especially at low overpotentials. 4,5 In this work, we present a comprehensive operando correlative study of dynamic evolution during the life cycle of a family of monodisperse Cu NP ensemble electrocatalysts under CO 2 RR. 1 Operando electrochemical liquid-cell scanning transmission electron microscopy (EC-STEM) and 4D-STEM resolves microscopic dynamic morphological and structural evolution at the nm scale. Correlated operando high-energy-resolution fluorescence-detector (HERFD) X-ray absorption spectroscopy (XAS) 6 reveals dynamic macroscopic changes in valence states and coordination environment. Statistical analysis of interparticle dynamics was probed by operando resonant soft X-ray-based small-angle X-ray scattering (SAXS). 2 The operando correlative strategies, described herein, elucidates the longstanding enigmatic nature of Cu active sites as metallic Cu nanograins for selective CO 2 electroreduction (Fig. 1). The strategy described herein can serve as a general platform to resolve the electrocatalytic interface of nanoparticle catalysts under real-time operating conditions across multiple time and length scales, thus serving the fundamental understanding necessary to development of many other electrochemical reactions for renewable energy technologies. References: Yang, Y., Yang, P. et al. Operando Studies Reveal Active Cu Nanograins for CO 2 Nature 2023, 614, 262. Yang, Y., Yang, P., et al. Operando Resonant Soft X-ray Scattering Studies of Chemical Environment and Interparticle Dynamics of Cu Nanocatalysts for CO2 J. Am. Chem. Soc . 2022, 144 , 8927−8931. Yang, Y., Abruña, H. D. et al. Operando Methods in Electrocatalysis. ACS Catal . 2021, 11, 1136-1178. Kim, D., Yang, P. et al. Copper Nanoparticle Ensembles for Selective Electroreduction of CO2 to C2−C3 Proc. Natl. Acad. Sci. U.S.A . 2017, 114, 10560−10565. Li, Y., Yang, P. et al. Electrochemically Scrambled Nanocrystals are Catalytically Active for CO2-to-Multicarbons. Natl. Acad. Sci. U.S.A . 2020, 117, 9194−9201. Feijoo, Yang, Y. et al. Operando High-Energy-Resolution X-ray Spectroscopy of Evolving Cu Nanoparticle Electrocatalysts for CO2 Reduction. J. Am. Chem. Soc. 2023, 145, 20208 Figure 1

ADVERTISEMENT RETURN TO ISSUEPREVViewpointNEXTExosomal NADPH Oxidase: Delivering Redox Signaling for HealingLakshmi KrishnamoorthyLakshmi KrishnamoorthyDepartment of Chemistry, University of California, Berkeley, California 94720, United StatesHoward Hughes Medical Institute, University of California, Berkeley, California 94720, United StatesMore by Lakshmi Krishnamoorthy and Christopher J. Chang*Christopher J. ChangDepartment of Chemistry, University of California, Berkeley, California 94720, United StatesHoward Hughes Medical Institute, University of California, Berkeley, California 94720, United StatesDepartment of Molecular and Cell Biology, University of California, Berkeley, California 94720, United StatesHelen Wills Neuroscience Institute, University of California, Berkeley, California 94720, United States*E-mail: [email protected]More by Christopher J. Changhttp://orcid.org/0000-0001-5732-9497Cite this: Biochemistry 2018, 57, 27, 3993–3994Publication Date (Web):June 11, 2018Publication History Received12 April 2018Published online11 June 2018Published inissue 10 July 2018https://pubs.acs.org/doi/10.1021/acs.biochem.8b00429https://doi.org/10.1021/acs.biochem.8b00429editorialACS PublicationsCopyright © 2018 American Chemical Society. This publication is available under these Terms of Use. Request reuse permissions This publication is free to access through this site. Learn MoreArticle Views1712Altmetric-Citations7LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail PDF (476 KB) Get e-AlertscloseSUBJECTS:Cells,Central nervous system,Lesions,Peptides and proteins,Regeneration Get e-Alerts

An impedance-based Point Defect Model (PDM) was developed for the potentiostatic, anodic formation of gold oxide at potentials of 1.40–1.70 V vs SHE in H 2 SO 4 (0.1 M and 0.5 M). Film thickness and refractive indices were determined at each oxide formation potential using spectroscopic ellipsometry. The thickness of the oxide increases linearly with increasing potential. Mott-Schottky analysis shows that the oxide exhibits both n-type and p-type character and the dominant defect density is calculated to be in the order of 10 21 −10 22 (1 cm −3 ). The PDM was optimized upon experimental EIS data to extract values for model parameters and accounts well for the experimental observations in both the steady-state time and frequency domains.