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An enzymatic microreactor with a volume of 470 nL has been prepared by immobilizing trypsin on a 10 cm long reactive porous polymer monolith located in a 100 microm i.d. fused silica capillary. This reactor affords suitable degrees of digestion of proteins even after very short residence times of less than 1 min. The performance is demonstrated with the digestion of eight proteins ranging in molecular mass from 2848 to 77 754. The digests were analyzed using mass spectrometry in two modes: off-line MALDI and in-line nanoelectrospray ionization. The large numbers of identified peptides enable a high degree of sequence coverage and positive identification of the proteins. The extent of sequence coverage decreases as the molecular mass of the digested protein increases.

We appreciate the comments by Dole et al. (2016), and we also appreciate their having shared these views with some of us (Richards, Renne, Sprain, and Vanderkluysen) on a joint field trip in January 2016. We agree with some of the issues raised in the comment, but these points do not undermine our basic conclusion that the stratigraphic transition from the Lonavala Subgroup to the Wai Subgroup within the Deccan Traps represents a fundamental change in the character of Deccan volcanism, and that this change was approximately coincident with the Cretaceous-Paleogene boundary. In fact, the geomorphic features in question are now understood to be a likely consequence of this fundamental change.

This study examines the association between scope of Quality Improvement (QI) implementation in hospitals and hospital performance on patient safety indicators. Secondary data sources included a 1997 survey of hospital QI practices, Medicare Inpatient Database, American Hospital Association's Annual Survey of Hospitals, the Bureau of Health Professions'Area Resource File, and two proprietary data sets. Using a sample of 1,784 community hospitals, the study employed two-stage instrumental variables estimation in which predicted values of four QI scope variables and control variables were used to estimate four patient safety indicators. Involvement by multiple hospital units in the QI effort is associated with worse values on all four patient safety indicators. Percentages of hospital staff and of senior managers participating in QI teams exhibited no statistically significant association with any patient safety indicator. Percentage of physicians participating in QI teams is associated with better values on two patient safety indicators.

We present on an optical antenna based nanoLED that is fabricated directly on top of an InP waveguide. Waveguide coupling efficiency of 70% and directional emission is achieved with a Yagi-Uda antenna structure. By using an epitaxial lift-off process, we show that this device could be integrated directly onto a Silicon-photonics substrate.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMolecular ethylene adsorption on rhodium(111) and rhodium(100): estimation of the carbon-carbon stretching force constant from the surface vibrational frequenciesB. E. Bent, C. M. Mate, C. T. Kao, A. J. Slavin, and Gabor A. SomorjaiCite this: J. Phys. Chem. 1988, 92, 16, 4720–4726Publication Date (Print):August 1, 1988Publication History Published online1 May 2002Published inissue 1 August 1988https://pubs.acs.org/doi/10.1021/j100327a032https://doi.org/10.1021/j100327a032research-articleACS PublicationsRequest reuse permissionsArticle Views167Altmetric-Citations50LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access options Get e-Alerts

Sequential covalent transformation and metalation were performed on (Zn(4)O)(3)(BDC-NH(2))(3)(BTB)(4) with maintenance of crystallinity and porosity. Reaction of (Zn(4)O)(3)(BDC-NH(2))(3)(BTB)(4) with 2-pyridinecarboxaldehyde in toluene at room temperature for 5 days resulted in the formation of the extended crystalline structure (Zn(4)O)(3)(BDC-C(6)H(5)N(2))(3)(BTB)(4), which possesses iminopyridine moieties covalently bound to the organic links of the framework. Subsequent reaction with PdCl(2)(CH(3)CN)(2) in CH(2)Cl(2) at room temperature for 12 h yielded the metalated metal-organic framework (Zn(4)O)(3)(BDC-C(6)H(5)N(2)PdCl(2))(3)(BTB)(4). Both functionalized materials retained high crystallinity and were permanently porous with high surface areas [3200 and 1700 m(2) g(-1) for (Zn(4)O)(3)(BDC-C(6)H(5)N(2))(3)(BTB)(4) and (Zn(4)O)(3)(BDC-C(6)H(5)N(2)PdCl(2))(3)(BTB)(4), respectively.].

Although reticular chemistry has commonly utilized mutually embracing tetrahedral metal complexes as crossing points to generate three-dimensional molecularly woven structures, weaving in two dimensions remains largely unexplored. We report a new strategy to access 2D woven COFs by controlling the angle of the usually linear linker, resulting in the successful synthesis of a 2D woven pattern based on chain-link fence. The synthesis was accomplished by linking aldehyde-functionalized copper(I) bisphenanthroline complexes with bent 4,4'-oxydianiline building units. This results in the formation of a crystalline solid, termed COF-523-Cu, whose structure was characterized by spectroscopic techniques and electron and X-ray diffraction techniques to reveal a molecularly woven, twofold-interpenetrated chain-link fence. The present work significantly advances the concept of molecular weaving and its practice in the design of complex chemical structures.