Publications

We present an observational study of the luminous red nova (LRN) AT\,2021biy in the nearby galaxy NGC\,4631. The field of the object was routinely imaged during the pre-eruptive stage by synoptic surveys, but the transient was detected only at a few epochs from $\sim 231$\,days before maximum brightness. The LRN outburst was monitored with unprecedented cadence both photometrically and spectroscopically. AT\,2021biy shows a short-duration blue peak, with a bolometric luminosity of $\sim 1.6 \times 10^{41}$\,erg\,s$^{-1}$, followed by the longest plateau among LRNe to date, with a duration of 210\,days. A late-time hump in the light curve was also observed, possibly produced by a shell-shell collision. AT\,2021biy exhibits the typical spectral evolution of LRNe. Early-time spectra are characterised by a blue continuum and prominent H emission lines. Then, the continuum becomes redder, resembling that of a K-type star with a forest of metal absorption lines during the plateau phase. Finally, late-time spectra show a very red continuum ($T_{\mathrm{BB}} \approx 2050$ K) with molecular features (e.g., TiO) resembling those of M-type stars. Spectropolarimetric analysis indicates that AT\,2021biy has local dust properties similar to those of V838\,Mon in the Milky Way Galaxy. Inspection of archival {\it Hubble Space Telescope} data taken on 2003 August 3 reveals a $\sim 20$\,\msun\ progenitor candidate with log\,$(L/{\rm L}_{\odot}) = 5.0$\,dex and $T_{\rm{eff}} = 5900$\,K at solar metallicity. The above luminosity and colour match those of a luminous yellow supergiant. Most likely, this source is a close binary, with a 17--24\,\msun\ primary component.

Abstract not Available.

An amendment to this paper has been published and can be accessed via a link at the top of the paper.

Abstract While vaccines and antivirals are now being deployed for the current SARS-CoV-2 pandemic, we require additional antiviral therapeutics to not only effectively combat SARS-CoV-2 and its variants, but also future coronaviruses. All coronaviruses have relatively similar genomes that provide a potential exploitable opening to develop antiviral therapies that will be effective against all coronaviruses. Among the various genes and proteins encoded by all coronaviruses, one particularly “druggable” or relatively easy-to-drug target is the coronavirus Main Protease (3CL pro or Mpro), an enzyme that is involved in cleaving a long peptide translated by the viral genome into its individual protein components that are then assembled into the virus to enable viral replication in the cell. Inhibiting Mpro with a small-molecule antiviral would effectively stop the ability of the virus to replicate, providing therapeutic benefit. In this study, we have utilized activity-based protein profiling (ABPP)-based chemoproteomic approaches to discover and further optimize cysteine-reactive pyrazoline-based covalent inhibitors for the SARS-CoV-2 Mpro. Structure-guided medicinal chemistry and modular synthesis of di- and tri-substituted pyrazolines bearing either chloroacetamide or vinyl sulfonamide cysteine-reactive warheads enabled the expedient exploration of structure-activity relationships (SAR), yielding nanomolar potency inhibitors against Mpro from not only SARS-CoV-2, but across many other coronaviruses. Our studies highlight promising chemical scaffolds that may contribute to future pan-coronavirus inhibitors.

Energy absorption capability is critical in biological and engineering materials, particularly when subjected to extreme compressive and impact loading. In the current work, we demonstrate how natural biological materials, like horns and hooves, control crack generation and propagation through lamellar and tubular structural designs. Inspired by these biological tissues, lamellar and tubular structures were fabricated via multi-material three-dimensional (3D) printing. The resulting bioinspired structures exhibit an impressive energy absorption density of ∼18.75 kJ kg−1, comparable to the performance of metal foams and bioinspired honeycomb structures. Introducing soft-hard interfaces in lamellar and tubules notably enhances impact energy absorption by approximately 167% compared to solid structures printed with a single material. The bioinspired structures maintain structural integrity even under high-strain-rate impacts of around 2,000 s−1, showcasing resistance to deformation and catastrophic failure. This bioinspired approach allows for a combined energy absorption capability in quasi-static compression and high-strain-rate impact scenarios.

We present observations of SN Hunt 248, a new supernova (SN) impostor in NGC 5806, which began a multistage outburst in 2014 May. The ‘2014a’ discovery brightening exhibited an absolute magnitude of M ≈ −12 and the spectral characteristics of a cool, dense outflow, including P Cygni lines of Fe ii, H i, and Na i, and line blanketing from metals. The source rapidly climbed and peaked at M ≈ −15 mag after two additional weeks. During this bright ‘2014b’ phase the spectrum became dominated by Balmer emission and a stronger blue continuum, similar to the SN impostor SN 1997bs. Archival images from the Hubble Space Telescope between 1997 and 2005 reveal a luminous (4 × 10^5 L_⊙) variable precursor star. Its location on the Hertzsprung–Russell diagram is consistent with a massive (M_(init) ≈ 30 M_⊙) cool hypergiant having an extremely dense wind and an Eddington ratio (Γ) just below unity. At the onset of the 2014a brightening, however, the object was super-Eddington (Γ = 4–12). The subsequent boost in luminosity during the 2014b phase probably resulted from circumstellar interaction. SN Hunt 248 provides the first case of a cool hypergiant undergoing a giant eruption reminiscent of outbursts from luminous blue variable stars (LBVs). This lends support to the hypothesis that some cool hypergiants, such as ρ Cas, could be LBVs masquerading under a pseudo-photosphere created by their extremely dense winds. Moreover, SN Hunt 248 demonstrates that eruptions stemming from such stars can rival in peak luminosity the giant outbursts of much more massive systems like η Car.

"Supermax" prisons, conceived by the United States in the early 1980s, are typically reserved for convicted political criminals such as terrorists and spies and for other inmates who are considered to pose a serious ongoing threat to the wider community, to the security of correctional institutions, or to the safety of other inmates. Prisoners are usually restricted to their cells for up to twenty-three hours a day and typically have minimal contact with other inmates and correctional staff. Not only does the Federal Bureau of Prisons operate one of these facilities, but almost every state has either a supermax wing or stand-alone supermax prison. The Globalization of Supermax Prisons examines why nine advanced industrialized countries have adopted the supermax prototype, paying particular attention to the economic, social, and political processes that have affected each state. Featuring essays that look at the U.S.-run prisons of Abu Ghraib and Guantanemo, this collection seeks to determine if the American model is the basis for the establishment of these facilities and considers such issues as the support or opposition to the building of a supermax and why opposition efforts failed; the allegation of human rights abuses within these prisons; and the extent to which the decision to build a supermax was influenced by developments in the United States. Additionally, contributors address such domestic matters as the role of crime rates, media sensationalism, and terrorism in each country’s decision to build a supermax prison