Publications

For a recent intermediate-luminosity transient, AT 2019krl in M74 (NGC 628) at a distance of only ~9.8 Mpc, extensive archival $\textit{Hubble Space Telescope (HST)}$, $\textit{Spitzer Space Telescope}$, and Large Binocular Telescope (LBT) imaging reveal a bright optical and MIR progenitor star. A peak was detected in the infrared with an absolute magnitude of $M_{4.5\,\mu {\rm m}} = -18.4$ mag, leading us to infer a visual-wavelength peak absolute magnitude of $-$13.5 to $-$14.5. The light curve from the pre-discovery archival data indicated no outbursts over the previous 16yr. The colors, magnitudes, and inferred temperatures of the progenitor best match a 13--14 M$_{\odot}$ yellow or blue supergiant, if only foreground extinction is taken into account, or a hotter and more massive star, if any additional local extinction is included. A pre-eruption spectrum of the star reveals strong H$\alpha$ emission having a narrow line core with a width of about 200 km s$^{-1}$ (FWHM) and with wings extending to $\pm$ 2000 km s$^{-1}$. The post-eruption spectrum is fairly flat and featureless with only H$\alpha$, Na I D, [Ca II], and the Ca II near-infrared triplet in emission, with very little change in the shape of H$\alpha$ over 120 days. As in many previous intermediate-luminosity transients, AT 2019krl shows remarkable similarities to both massive luminous blue variable (LBV) eruptions and SN 2008S-like events. However, in this case, the information about the pre-eruption star allows us to clearly rule out both a super-AGB star and an electron-capture SN as the origin of this SN 2008S-like event. Instead, the data favor either a relatively unobscured blue supergiant (likely viewed pole-on) or a highly extinguished LBV with $M >$ 20 M$_{\odot}$, confirming that BSGs or LBVs that may undergo mergers are a viable progenitor pathway to produce SN 2008S-like events.

<div>Abstract<p>Natural killer (NK) cells can recognize and kill tumor cells lacking “self” markers, such as class I MHC, but the basis for this recognition is not completely understood. NKR-P1 receptors are members of the C-type lectin-related NK receptor superfamily that are conserved from rodents to humans. Identification of Clr ligands for the NKR-P1 receptors has facilitated functional analysis of MHC-independent target cell recognition by NK cells. One receptor-ligand pair, NKR-P1B:Clr-b, can mediate “missing-self” recognition of tumor and infected cells, but the role of this axis in sensing stressed cells remains unknown. Here, we show that Clr-b is rapidly downregulated in cells undergoing genotoxic and cellular stress at the level of both RNA and surface protein. Stress-mediated loss of Clr-b on leukemia cells enhanced cytotoxicity mediated by NKR-P1B<sup>+</sup> NK cells. Notably, Clr-b downregulation was coordinated functionally with stress-mediated upregulation of NKG2D ligands (but not class I MHC). Our findings highlight a unique role for the MHC-independent NKR-P1B:Clr-b missing-self axis in recognition of stressed cells, and provide evidence of two independent levels of Clr-b regulation in stressed cells. Cancer Res; 70(18); 7102–13. ©2010 AACR.</p></div>

By directly altering microscopic interactions, pressure provides a powerful tuning knob for the exploration of condensed phases and geophysical phenomena. The megabar regime represents an exciting frontier, where recent discoveries include novel high-temperature superconductors, as well as structural and valence phase transitions. However, at such high pressures, many conventional measurement techniques fail. Here, we demonstrate the ability to perform local magnetometry inside of a diamond anvil cell with sub-micron spatial resolution at megabar pressures. Our approach utilizes a shallow layer of Nitrogen-Vacancy (NV) color centers implanted directly within the anvil; crucially, we choose a crystal cut compatible with the intrinsic symmetries of the NV center to enable functionality at megabar pressures. We apply our technique to characterize a recently discovered hydride superconductor, CeH$_9$. By performing simultaneous magnetometry and electrical transport measurements, we observe the dual signatures of superconductivity: local diamagnetism characteristic of the Meissner effect and a sharp drop of the resistance to near zero. By locally mapping the Meissner effect and flux trapping, we directly image the geometry of superconducting regions, revealing significant inhomogeneities at the micron scale. Our work brings quantum sensing to the megabar frontier and enables the closed loop optimization of superhydride materials synthesis.

In this paper, the structures of the discrete-time cellular neural network (DTCNN) are modified for the purpose of implementation of binary mathematical morphology operations. The structure of a DTCNN for implementation of the four basic mathematical morphology operations: dilation, erosion, opening and closing are given. Two single layer DTCNNs are used to implement binary dilation and binary erosion, and two 2-layer DTCNNs are used to implement binary opening and binary closing, respectively. Simulation results are given.

No abstract is provided for this article.

This study offers a detailed mechanistic investigation of host-guest encapsulation behavior in a new enzyme-mimetic metal-ligand host and provides the first observation of a conformational selection mechanism (as opposed to induced fit) in a supramolecular system. The Ga₄L₄ host described features a C₃-symmetric ligand motif with meta-substituted phenyl spacers, which enables the host to initially self-assemble into an S₄-symmetric structure and then subsequently isomerize to a T-symmetric tetrahedron for better accommodation of a sufficiently large guest. Selective inversion recovery ¹H NMR studies provide structural insights into the self-exchange behaviors of the host and the guest individually in this dynamic system. Kinetic analysis of the encapsulation-isomerization event revealed that increasing the concentration of guest inhibits the rate of host-guest relaxation, a key distinguishing feature of conformational selection. A comprehensive study of this simple enzyme mimic provides insight into analogous behavior in biophysics and enzymology and aims to inform the design of efficient self-assembled microenvironment catalysts.

Boron-containing molybdenum silicides have been the focus of significant research of late due to their potentially superior low-temperature “pest” resistance and high-temperature oxidation resistance comparable to that of MoSi2-based silicides; however, like many ordered intermetallics, they are plagued by poor ductility and toughness properties. Of the various multiphase Mo–Si–B intermetallic systems available, alloys with compositions of Mo–12Si–8.5B (at.%), which contain Mo, Mo3Si, and T2 phases, are anticipated to have higher toughnesses because of the presence of the relatively ductile Mo phase. In this study, we examine the ambient to high (1300°C) temperature fracture toughness (R-curve) and fatigue-crack growth characteristics of Mo-12Si-8.5B, with the objective of discerning the salient mechanisms governing crack growth. It is found that this alloy displays a relatively high intrinsic (crack-initiation) toughness at 800 up to 1200°C (∼10 MPa√m), but only limited extrinsic R-curve (crack-growth) toughness. Although the lack of extrinsic toughening mechanisms is not necessarily beneficial to quasi-static properties, it does imply in a brittle material that it should show only minimal susceptibility to premature failure by fatigue, as is indeed observed at temperatures from ambient to 1300°C. Of particular significance is that both the fracture toughness and the threshold stress intensity for fatigue are increased with increasing temperature over this range. This remarkable property is related to a variety of toughening mechanisms that become active at elevated temperatures, specifically involving crack trapping by the α-Mo phase and extensive microcracking primarily in the Mo5SiB2 phase.