2,979 publications from this institution
In Neurospora crassa, expression from an unpaired gene is suppressed by a mechanism known as meiotic silencing by unpaired DNA (MSUD). MSUD utilizes common RNA interference (RNAi) factors to silence target mRNAs. Here, we report that Neurospora CAR-1 and CGH-1, homologs of two Caenorhabditis elegans RNA granule components, are involved in MSUD. These fungal proteins are found in the perinuclear region and P-bodies, much like their worm counterparts. They interact with components of the meiotic silencing complex (MSC), including the SMS-2 Argonaute. This is the first time MSUD has been linked to RNA granule proteins.
We introduce and study the use of the concept of granular correlation. Granular correlation arises as a result of introducing fuzzy information granules and can be regarded as a generic vehicle of data mining. It is shown how an analysis of fuzzy granular correlation helps reveal and quantify relationships between variables in any task of data mining. This analysis sheds light on an important issue of statistical relevance of granular associations in data sets.