Publications

Vasopressinergic V1 receptor agonists, such as arginine vasopressin (AVP) and terlipressin (TP), are increasingly used to stabilize haemodynamics in catecholamine-refractory hyperdynamic septic shock [1]. In the current sepsis guidelines, however, norepinephrine (NE) and dopamine are still recommended as vasopressors of choice [2]. The present study was designed as a prospective, randomized, controlled laboratory experiment to elucidate the effects of AVP and TP (when given as first-line therapy) on mesenteric blood flow (Qma) and mortality in an established model of ovine septic shock.

In this retrospective study, a higher FFP:RBC ratio was associated with a lower requirement for advanced interventional procedures in the setting of postpartum hemorrhage. The benefits of transfusion using a higher FFP:RBC ratio should be confirmed by randomized-controlled trials.

During liver transplantation, the RER can reliably predict postoperative complications. Implementing this measure intraoperatively may provide a warning for physicians of impending complications and justify more aggressive optimization of oxygen delivery. Further studies are required to determine whether correcting the RER is feasible and could reduce the incidence of complications.

PGI2 and dobutamine at the doses used have similar effects on oxygen extraction in critically ill, septic patients, but dobutamine increases DO2 more consistently and is better tolerated than prostacyclin.