2,833 publications from this institution
Over the 10-year period between 2002 and 2012, the proportion of patients with sepsis admitted to European ICUs remained relatively stable, but the severity of disease increased. In multilevel analysis, the odds of ICU mortality were lower in our 2012 cohort compared to our 2002 cohort, particularly in patients with sepsis.
It is evident that the patient with sepsis needs immediate attention to allow rapid and effective intervention. Recently, the Sepsis-3 Definitions task force used multivariable logistic regression to develop the qSOFA—a short sequential organ failure assessment (SOFA) score that incorporates a systolic blood pressure of 100 mmHg or less, a respiratory rate of 22/min or greater and/or an acute alteration in mentation—to be used as a means of identifying infected patients on the general ward who may need urgent attention and further workup for possible sepsis (1,2).
info:eu-repo/semantics/published
Life expectancy is rising worldwide and increasing numbers of elderly patients are being admitted to the intensive care unit (ICU). Because ageing is associated with changes in organ function, increased frailty, reduced activities of daily living, reduced mobility, and reduced cognition, elderly patients represent a particular subgroup of ICU patients. Ethical decisions related to the appropriateness of intensive care and/or life-sustaining interventions, the withdrawing and withholding of life support, and terminal sedation are more frequent in these patients and will be discussed in this review. Such decisions must be tailored to the individual to take into consideration personal beliefs and wishes.
clinicaltrials.gov Identifier: NCT01021631.
We describe a patient who experienced a prolonged episode of hypoglycemia secondary to an acute voluntary intoxication with diphenylhydantoin 20 g and zopiclone 225 mg. This hypoglycemic episode was presumptively attributed to diphenylhydantoin and might be due either to an escape from the inhibitory effects of diphenylhydantoin on insulin secretion or an increased sensitivity of the tissues to insulin. Zopiclone was considered less likely since zopiclone overdoses have been only exceptionally associated with hyperglycemia.
