Abstract Using computer simulation we explore the consequences of linkage on the inbreeding load of an equilibrium population, and on the efficiency of purging and the loss of genetic diversity after a reduction in population size. We find that linkage tends to cause increased inbreeding load due to the build up of coupling groups of (partially) recessive deleterious alleles. It also induces associative overdominance at neutral sites but rarely causes increased neutral genetic diversity in equilibrium populations. After a reduction in population size, linkage can cause some delay both for the expression of the inbreeding load and the corresponding purging. However, reasonable predictions can be obtained for the evolution of fitness under inbreeding and purging by using empirical estimates of the inbreeding depression rate. Purging selection against homozygotes for deleterious alleles affects the population’s pedigree. Furthermore, it can slow the loss of genetic diversity compared to that expected from the variance of gametic contributions to the breeding group and even from pedigree inbreeding. Under some conditions, this can lead to a smaller loss of genetic diversity, even below that expected from population size in the absence of selection.
Genetic diversity within a population is a critical parameter for conservation biologists to assess. One approach for examining genetic diversity is through the determination of effective population sizes. Animal Conservation recently published a review of genetic approaches for estimating effective population sizes. We felt this review was incomplete both methodologically and conceptually. Here we extend that review to include coalescent-based approaches for estimating effective population sizes. We then discuss different kinds of effective population sizes, including inbreeding, variance and eigenvalue effective sizes.
Hermida, R. C.; Calvo, C.; Ayala, D. E.; Dominguez, M. J.; Covelo, M.; Mojon, A.; Fernandez, J. R.; Fontao, M. J.; Soler, R.; Lopez, J. E. Author Information