Publications

Multiple nanoparticle-based approaches to counter bacterial infections, providing crucial insight into the design of elements that play critical roles in the creation of antimicrobial nanotherapeutic drugs, are currently underway. In this context, plant-based nanoparticles will be less toxic than many other forms, which constitute promising candidates to avoid widespread damage to the microbiome associated with current practices. This article aims to review the actual knowledge on plant-based nanoparticle products for antibiotic resistance and the possible replacement of antibiotics to treat multidrug-resistant bacterial infections.

Significant evidence from epidemiological investigations showed that dietary polyphenols might manage and prevent type 2 diabetes (T2D). This review summarizes human studies and clinical trials of polyphenols as anti-diabetic agents. Polyphenols from coffee, guava tea, whortleberry, olive oil, propolis, chocolate, red wine, grape seed, and cocoa have been reported to show anti-diabetic effects in T2D patients through increasing glucose metabolism, improving vascular function as well as reducing insulin resistance and HbA1c level. However, individual flavonoid or isoflavonoid compounds appear to have no therapeutic effect on diabetes, based on the limited clinical data. Preliminary clinical trials provided evidence that resveratrol had anti-diabetic activity in humans by improving glycemic control in subjects with insulin resistance. Besides, anthocyanins exhibited anti-diabetic properties by reducing blood glucose and HbA1c levels or the improvement of insulin secretion and resistance. The structure-activity relationship of polyphenols as anti-diabetic agents in humans has been rarely reported.

The 2021 online editorial board meeting of the <i>World Journal of Diabetes</i> (<i>WJD</i>) was held on November 9, 2021. Jin-Lei Wang, General Manager on behalf of the Baishideng Publishing Group, and Professor Islam, one of the Editors-in-Chiefs (EiCs) of the <i>WJD</i>, organized the meeting. Three EiCs and 18 Baishideng Publishing Group staff attended the meeting. The meeting goal was to brief the EiCs on the journal's performance, discuss the issues of concern of the EiCs, and gather ideas for the journal's development in 2022. As of November 8, the <i>WJD</i> had received 287 manuscripts since the year's start, among which 122 met the criteria for publication. These numbers represent an increase of 117.4% for submissions and 110.3% for publications compared to those in 2020. However, how to effectively control the academic quality of manuscripts and attract high-quality original article submissions remain a challenge. The EiCs provided feedback and suggestions centered on three topics: (1) Who should and how to control the academic quality of the manuscripts; (2) How the EiCs perform their responsibilities; and (3) The distinctive and shared responsibilities of the publisher and the EiCs.

Abstract Rhodiola species, belonging to the family Crassulaceae, have long been used as an adaptogen, tonic, antidepressant, and antistress medicine or functional food in Asia and Europe. Due to the valuable application, the growing demand of Rhodiola species has led to a rapid decrease in resource content. This review aims to summarize the integrated research progress of seven mainstream Rhodiola species. We first outline both traditional and current use of Rhodiola for the treatment of various diseases. A detailed summary and comparison of chemical, pharmacological, toxicological, and clinical studies of various Rhodiola species highlight recent scientific advances and gaps, which gives insights into the understanding of Rhodiola application and would be helpful to improve the situation of biological resources and diversities of Rhodiola plants.

A new procedure that uses a preconcentration system based on solid phase microextraction (SPME) and detection by quartz furnace atomic absorption spectrometry after thermal desorption from the microextraction fiber has been proposed for the determination of tetraethyllead in gasoline (leaded and unleaded) and water. Three different volatilizators were designed and their influence in the thermal desorption of tetraethyllead was studied. Working tetraethyllead solutions were prepared in 40 ml amber vials and sampling was performed by exposing the SPME fiber to the headspace over vigorously stirred samples for 10 min. The analytical performance characteristics of the proposed procedure were as follows: the detection limit for tetraethyllead was 0.43 ng ml−1, with a relative standard deviation of 6% for determination of 10 ng ml−1 of tetraethyllead (n = 5) while the calibration curve was linear up to 50 ng ml−1 range. The proposed procedure was finally applied to the determination of tetraethyllead in gasoline and water samples obtaining a good agreement with those values obtained by an alternative method that included the direct injection of tetraethyllead, via a septum, in the heated volatilizator with a gas chromatographic syringe, the tetraethyllead volatilisation and its transport by the gas carrier to the quartz furnace, where the analytical signal was observed. This procedure could be easily adapted for the speciation of ionic lead and tetraethyllead.

Molineria capitulata is an ornamental plant that has traditionally been used to treat several chronic diseases. The present study was designed to examine the antioxidant, cytotoxic, thrombolytic, anti-inflammatory, and analgesic activities of a methanolic extract of M. capitulata leaves (MEMC) using both experimental and computational models. Previously established protocols were used to perform qualitative and quantitative phytochemical screening in MEMC. A computational study, including molecular docking and ADME/T analyses, was performed. The quantitative phytochemical analysis revealed the total phenolic and flavonoid contents as 148.67 and 24 mg/g, respectively. Antioxidant activity was assessed by examining the reducing power of MEMC, resulting in absorbance of 1.87 at 400 µg/mL, demonstrating a strong reduction capacity. The extract exhibited significant protection against blood clotting and showed the highest protein denaturation inhibition at 500 µg/mL. In both the acetic acid-induced writhing and formalin-induced paw-licking models, MEMC resulted in significant potential pain inhibition in mice. In the computational analysis, 4-hydroxybenzaldehyde, orcinol glucoside, curcapital, crassifogenin C, and 2,6-dimethoxy-benzoic acid displayed a strong predictive binding affinity against the respective receptors. These findings indicated that M. capitulata possesses significant pharmacological activities to an extent supported by computational studies.