717 publications from this institution
This paper describes voltage balancing of all the four split dc capacitors for a five-level diode-clamped PWM inverter intended for a transformerless mediumvoltage motor drive with a three-phase diode rectifier used as the front end. A dc-voltage-balancing circuit is installed on the dc link, and introduces a new midpoint-voltage-balancing method based on phase-shift control. As a result, the dc mean voltages of the four split dc capacitors can be balanced, independent of the inverter control. Experimental results obtained from the 200-V 5.5-kW downscale model verify that the dc mean voltage of the four split capacitors are balanced well under all the operating conditions.
Aberrant O-glycosylation of serum and tonsillar IgA1 is one of the main pathogeneses of IgA nephropathy (IgAN). However, the synthesis of underglycosylated IgA1 in tonsils has not yet been characterized. This study examined tonsillar B lymphocytes of IgAN (n =34) using tonsils derived from patients with chronic tonsillitis (n =24) and sleep apnea syndrome (n =14) as a control. Gene expression of β1,3-galactosyltransferase (β3GalT), and the core 1 β3GalT-specific molecular chaperone, Cosmc, UDP-N-acetyl-α-D-galactosamine: polypeptide N-acetylgalactosaminyl-transferase 2, were significantly decreased in tonsillar CD19-positive B lymphocytes from IgAN patients compared to control tonsillar tissues as determined by real-time RT-PCR. Tonsillar B cell β3GalT gene expression significantly correlated with estimated GFR and negatively correlated with proteinuria and histological injury score. Western blotting showed the protein expression of β3GalT in the tonsils to significantly decrease in IgAN in comparison to the controls. These data suggest the downregulation of β3GalT in tonsillar B lymphocytes to be closely associated with the clinical characteristics of IgAN.