173 publications from this institution
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Recent progress in the area of intramolecularly coordinated organochalcogens, in particular, organoselenium derivatives, is reviewed. Intramolecular coordination facilitates isolation of (a) stable organoselenenyl iodides, (b) chiral diselenides, (c) organotriselenides, d) cleavage of Te─C bond, e) metal-free synthesis of chalcogenaaza macrocycles, and f) isolation of cyclic selenenate esters. The synthesis of organoselenium compounds incorporating two ortho-coordinating groups is also discussed.
A report of the first 100 patients treated in the multidisciplinary Dysphagia Clinic in Salisbury District Hospital is presented. It was established in January 1992 and involves the Departments of ENT Surgery, Clinical Radiology and Speech and Language Therapy. In the first 18 months, 100 patients have been assessed and treated. These included 46 males and 54 females, between the ages of four and 93 years. Neurological problems accounted for 39 cases. The management comprised the assessment clinic, videofluoroscopy in 83 patients, and finally the appropriate treatment. Forty-four patients were treated primarily by swallowing therapy. Seventy-three patients showed complete recovery, resolution of their symptoms or did not require treatment. Two patients were still under treatment at the time of writing this paper.
Abstract Se―N heterocycles have emerged as a promising class of bioactive molecules due to their unique redox properties and structural versatility. Such compounds exhibit good antioxidant activity and effectively mimic the function of glutathione peroxidase (GPx), a key enzyme in oxidative stress regulation. Among them, ebselen (2‐phenyl‐1,2‐benzoisoselenazol‐3‐[2 H ] one), a five‐membered Se―N heterocyclic compound and its analogues have been extensively studied for their anti‐inflammatory and neuroprotective roles. Selenazoles, selenadiazoles, spiroselenuranes, and selenoxides further expand the organoselenium landscape, offering diverse mechanisms of biological action. Recent advances underscore their potential in therapeutic applications including cancer, neurodegeneration, and ferroptosis. This review highlights the structural evolution and biological relevance of Se―N heterocycles as emerging enzyme mimetics and drug candidates for future therapeutics in diseases under oxidative stress.
ABSTRACT The present study is aimed at investigating the hydroperoxide scavenging activity and chemical mechanisms of the selected organoselenium compounds (diphenyl selenoxide, diphenyl selenide, and diphenyl diselenide) in reaction with model lipid hydroperoxide—cumene hydroperoxide. The reaction products were identified using GC–MS, HPLC, FT‐IR, and 1 H NMR techniques. The yield of free radicals was determined by the spin‐trap ESR study and inhibitors' method and evaluated to be less than 10 −5 within the accuracy of the used methods. It was established that the main products of the conversion of cumene hydroperoxide in the reaction with selected organoselenium compounds are dimethyl phenyl carbinol, acetophenone, and α ‐methylstyrene. The chemical mechanism of the antihydroperoxide action of selenium compounds has been suggested. The key lies in their ability to engage in multiple chemical pathways simultaneously. Notably, two‐electron transfer reactions take center stage, effectively neutralizing the hydroperoxides without generating strong reactive oxygen species—free radicals.
Microservices Architecture (MSA) signifies a critical approach in the efforts by the organizations to improve the agility, scalability and effectiveness of their systems in contemporary enterprise environments. Nonetheless, this change is associated with technical, organisational, and process-related challenges that introduce significant risks, which can result in project abandonment, performance degradation, or migration failure. This paper presents a comprehensive qualitative risk-oriented analysis. A systematic literature review covering the period from 2018 to 2024 and qualitative risk analysis are used to assess the impact and probability of each challenge and to create a prioritised risk matrix with an extensive mitigation structure. Key findings are highlighted as critical risks, including shared database dependencies, lack of DevOps maturity, and organisational resistance (risk score = 9) and high priority risks that include security vulnerabilities and insufficient monitoring (risk score = 6). Suggested mitigation strategies include domain-driven design, event-driven architecture, the CQRS pattern, CI/CD pipeline enhancement, and structured change management schemes. Presenting a coherent risk prioritisation model, this study provides a strong foundation for architects, technology leaders, and researchers to develop their resilient SOA-to-MSA migration strategies, thereby contributing practical value to the software engineering literature.
Diphenyl disulfides carrying alkyltelluro groups in the o-, m-, and p-positions were prepared using ortho-lithiation and lithium halogen exchange reactions. The novel antioxidants showed only minimal inhibitory effect on the azo-initiated peroxidation of linoleic acid in chlorobenzene until reduced to the corresponding thiophenols by tris(2-carboxyethyl)phosphine (TCEP). The best in situ generated thiophenol (from 7c) under these conditions quenched peroxyl radicals more efficiently than α-tocopherol with an almost 3-fold increase in inhibition time.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Views Icon Views Article contents Figures & tables Video Audio Supplementary Data Peer Review Share Icon Share Twitter Facebook Reddit LinkedIn Tools Icon Tools Reprints and Permissions Cite Icon Cite Search Site Citation Ritika Sachdeva, Prabhjot Kaur, V. P. Singh, G. S. S. Saini; Density functional theory studies of etoricoxib. AIP Conf. Proc. 6 May 2016; 1728 (1): 020530. https://doi.org/10.1063/1.4946581 Download citation file: Ris (Zotero) Reference Manager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentAIP Publishing PortfolioAIP Conference Proceedings Search Advanced Search |Citation Search
<abstract><title><italic>Abstract.</italic></title> The flow duration curve (FDC) is employed for addressing a multitude of problems in water resources engineering, such as prediction of the distribution of future flows, forecasting of future recurrence frequencies, comparison of watersheds, construction of load duration curves, and determination of low flow thresholds. Usually, the FDC is constructed empirically for a given set of flow data, and the FDC so constructed is found to vary from one year to another and from one gauging station to another within the same watershed. This article attempts to analytically derive the FDC by maximizing the Tsallis entropy based on the knowledge that the mean discharge is known, thus obviating the need for any fitting. The mean discharge is found to be strongly related to the drainage area. The Tsallis entropy-based FDC is tested using field data and is found to be in agreement with the observed curve. The entropy method permits a probabilistic characterization of the FDC and hence a quantitative assessment of its uncertainty. With this method, the flow duration curve can also be forecasted for different recurrence intervals. The entropy is found to monotonically increase with the increase in time interval, indicating that the flow system becomes more complex but the degree of complexity decreases with increasing time interval after a certain time, eventually reaching a constant value, reflecting a reduced influence of land use change and other human influences on the flow regime.
We investigated the pharmacological profile of licofelone [6‐(4‐chlorophenyl)‐2,3‐dihydro‐2,2‐dimethyl‐7‐phenyl‐1H‐pyrrolizine‐5‐acetic acid] against different inflammogens. The anti‐inflammatory and anti‐hyperalgesic effect of licofelone (2, 30 and 100 mg/kg, p.o.) against all the challenges was statistically significant ( P < 0.05) when compared with control and indomethacin (10 mg/kg, p.o.). The ED 50 value of 19.1 mg/kg (onset by 2 h, duration: short), 13.0 mg/kg and 16.8 mg/kg (onset by 1 h, duration: long) was observed for licofelone against carrageenan‐, arachidonic acid‐ and bradykinin‐induced paw oedema, respectively. Similarly, licofelone showed ED 50 value of 47.6 mg/kg (onset by 1 h, duration: long), 92.2 mg/kg (onset by 1 h, duration: medium), and 78.6 mg/kg (onset by 2 h, duration: medium) against carrageenan‐, arachidonic acid‐ and bradykinin‐induced mechanical hyperalgesia, respectively. The rank order of potency based on percent inhibition and percent reversal against inflammation and mechanical hyperalgesia, respectively, was found to be licofelone > indomethacin. Moreover, licofelone (10–100 mg/kg, p.o.) significantly ( P < 0.05) and dose‐dependently prevented the Freund's adjuvant‐induced increased vascularity in mice (vascularity index; 10 mg/kg: 0.059 ± 0.015; 20 mg/kg: 0.048 ± 0.004; 30 mg/kg: 0.039 ± 0.012; 100 mg/kg: 0.025 ± 0.015 vs. control: 0.0285 ± 0.003). Furthermore, the results suggested that dual inhibitors of cyclooxygenase and lipoxygenase like licofelone provide an effective control of inflammation and hyperalgesia against acute inflammation/hyperalgesia in rats and mice.
The present study was aimed to evaluate the effect of licofelone, a dual inhibitor of cycloxygenase1/2-5-lipoxygenase against indomethacin-induced gastric damage in rats and mice in order to assess the role of leukotrienes if any, in non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastrointestinal inflammation. Acute pretreatment with licofelone reversed the indomethacin-induced gastric ulceration, neutrophil adhesion in mesentery venules, neutrophil count in blood, lipid peroxides and vascularity in the stomachs of mice and rats. Further, chronic pretreatment of licofelone also prevented indomethacin-induced gastric morphological changes and cellular infiltration in mesentery venules. Moreover, acute administration of indomethacin elevated leukotriene B4 levels in gastric mucosa, which was reversed by pretreatment with licofelone The results suggest that licofelone offered gastroprotection against NSAIDs-induced gastropathy through its effect on leukotrienes and by inhibiting extravasation of neutrophils.
Antidepressant drugs are reported to be used as co-analgesics in clinical management of migraine and neuropathic pain. The mechanism through which they alleviate pain remains unknown. The present study explores the possible mechanism of a selective serotonin reuptake inhibitor (SSRI) fluoxetine-induced antinociception in animals. Acetic acid-induced writhing, hot plate and tail-flick test were used to assess fluoxetine-induced antinociception. Fluoxetine (5–20 mg kg−1, i.p.) produced a significant and dose-dependent antinociceptive effect against acetic acid-induced writhing in mice. Fluoxetine (20 mg kg−1) also exhibited antinociceptive effect in tail flick as well as hot plate assays. Further, i.c.v. administration of fluoxetine showed significant antinociception against writhing test in rats. However, fluoxetine (1 μg/10 μl/rat, i.c.v.) did not exhibit any antinociceptive effect in serotonin-depleted animals. Further, pindolol (10 mg kg−1, i.p.) enhanced fluoxetine-induced antinociceptive effect. The antinociceptive effect of fluoxetine was sensitive to blockade by naloxone (5 mg kg−1, i.p.) and naltrexone (5 mg kg−1, i.p.). These data suggest that fluoxetine-induced antinociception involves both central opioid and the serotoninergic pathways.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
