In recent years, panel PET is an interesting field in medical imaging. But the major obstacle of panel PET is the limited view problem. Images reconstructed by traditional algorithms will suffer serious artifacts. Time-of-flight (TOF) information can be incorporated into the image reconstruction to remove the artifacts. However, the best system timing resolution available in current commercial PET scanners is about 500 ps, which is not precise enough to achieve satisfactory images. In this paper, a list mode reconstruction algorithm coupled with non-local means regularizer was formulated to improve the panel PET image quality. It incorporates the anatomical information into the non-local means regularizer and modifies the reconstructed image while it is updating. The results show that our proposed method could remove the distortions effectively without TOF information.
Abstract Background: Many patients with cancer have benefited from immunotherapy represented by the blockade of immune checkpoint PD-1/PD-L1. However, about 4-29% of cancer patients treated with immunotherapy developed hyper-progressive diseases(HPD) with accelerated tumor growth. MDM2/MDM4 amplification was suggested as genomic correlates for elevated risk hyperprogression. The objective of this study was to evaluate the frequency of amplification of MDM2/MDM4 in the Chinese solid tumor patients and to provide advice on the selecting of optimal treatment decisions. Methods: Tumor or blood samples were collected from 2,937 patients with solid cancer, genetic mutations and amplification was detected using the next-generation sequencing(NGS). Results: A total 112 patients with MDM2/MDM4 amplification were identified, including lung cancer 50.9% (57/112), colorectal cancer 14.3% (16/112), gastric cancer 8.0% (9/112), liver cancer 5.4% (6/112), Biliary tract cancers 4.5% (5/112), breast cancer 2.7% (3/112), and pancreatic ductal adenocarcinoma 2.7% (3/112). TMB value was identified, The median TMB for lung cancer was 9.13 mutations/Mb, median TMB for colorectal cancer was 13.8 mutations/Mb, a high TMB value in gastric cancer (median TMB=20.22 mutations/Mb), and median TMB for liver cancer was 17.9 mutations/Mb. Meanwhile, MSI was detected in 8% of patients with MDM2/MDM4 amplification, of which 3 in lung cancer, 5 in colorectal cancer, and 1in gastric cancer. Conclusions: Although amplification of MDM2/MDM4 was observed only in a small proportion of patients, it demonstrated an association with high TMB in several common cancer types. In addition, our data indicate that amplification of MDM2/MDM4 in different types of cancer is heterogeneous and that an appropriate immunotherapy strategy for patients with solid cancer should be noted. Citation Format: xiangyu sun, Zhichao Fu. A comprehensive pan-cancer analysis of MDM2/MDM4 gene amplification in Chinese solid cancer patients [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5844.
Abstract The effect of high Cu2+ stress on fermentation performance and copper biosorption of Saccharomyces cerevisiae BH8 during wine fermentation was investigated in this paper. Under high Cu2+ stress, the cell growth and survival rate of yeast BH8 were inhibited. With different copper concentration, the effect on cell growth of yeast BH8 was different. What’s more, high Cu2+ stress could inhibit the fermentation property, alcohol production and reducing sugar utilization of yeast BH8 in Chardonnay grape must, but not significant. And the trend of the copper ion concentration falling down was consistent with the trend of yeast growth rising up, meanwhile the copper content was still much less than the initial concentration after fermentation. In addition, yeast BH8 showed a good fermenting property and copper removal ability under high Cu2+ stress. These results could provide certain reference and some new data for the wine industry to face the copper pollution risk.
Due to stricter municipal wastewater discharge standards, there is an increased need for further treatment of nitrate in the secondary effluent of wastewater treatment plants. This is achieved through denitrification by the addition of external carbon sources, which leads to increased costs in wastewater treatment. The aim of this study was to examine the possibility of simultaneous removal of nitrate and phosphorus from simulated secondary effluent by employing a sponge-iron-based denitrifying filter at room temperature. The results indicate that at hydraulic retention times of over 2 h, more than 60% of the nitrate was reduced to ammonia and nitrite via iron-based abiotic nitrate reduction. However, sponge iron easily scaled after two months of operation. Therefore, a little glucose was added to the influent, resulting in a final COD/N ratio of 1:1. Mixotrophic nitrate reduction was observed, and the rust of sponge iron was successfully dissolved. Batch test results demonstrate that biological nitrate denitrification accounted for 70.0% of the total nitrate reduction. Additionally, high-efficiency phosphorus removal through the chemical reaction of released iron and phosphorus was achieved throughout the entire experiment, with removal efficiencies of more than 90% at hydraulic retention times of over 2 h. Moreover, high-throughput sequencing data show that the species diversity obviously increased after adding organic carbon, suggesting the coexistence of heterotrophic and autotrophic denitrifiers. Hence, the sponge-iron denitrifying filter has considerable prospects in the field of secondary effluent treatment and is likely to be the future direction of zero-valent iron application in sewage treatment.
The nutritional properties and biological activities of kiwifruit and their different products made from same raw kiwifruit were investigated.
We investigate the impact of uncertainty of uncertainty (UOU) on corporate accounting conservatism, finding a positive association. Mechanism analysis suggests that under UOU, creditor demands for real information drives shifts toward accounting conservatism. Further analysis shows that the impact of UOU is more salient in non-SOEs, and firms with weak external monitoring mechanisms. Our study highlights that under uncertainty about levels of uncertainty, contract demand plays a significant role in corporate governance.
The effects of copper pollution on the polyphenol content, color, and antioxidant activity of wine, as well as correlations among these factors, were investigated. Copper had clear influences on wine polyphenol content. At low copper concentrations, the concentrations of nearly all polyphenols increased, and the antioxidant activity values of the wine also increased. When the copper concentration reached the lowest level of the medium copper range (9.6~16 mg/L), most of the indices also improved. When the copper concentrations reached the latter part of the medium copper range (19.2 and 22.4 mg/L), many of the tested indices began to decrease. Furthermore, when the copper concentration reached the high ranges (32, 64, and 96 mg/L), the polyphenol content, CIELAB color parameters, and antioxidant activity of wine were substantially decreased, indicating the need to control increasing copper content in grape must.
