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No abstract is provided for this article.
Tlie role of histidine becomes important at pH 5. Ability to form His^Ag’ complexes decreases with the gelatin oxidation. A relation is found between the content of the gelatin histidine residues involved in the Ag ’binding and the gelatin methionine content.
The syntheses of some thymidine analogues, including 2'-deoxy-5-ethynyluridine and E-5-(2-bromovinyl)-2'-deoxyuridine are outlined. Some of these compounds show significant anti-herpes activity in vitro.
Until 1963, only viruses were known to stimulate interferon production in cells. The nucleic acid of the virus was generally regarded as the essential stimulus for interferon production.<sup>1</sup>Rotem et al and Isaacs et al<sup>2,3</sup>demonstrated in 1963 that nonviral nucleic acids, provided they were foreign to the cells (heterologous or chemically modified homologous RNA), could also initiate the production of interferon. Although their "foreign nucleic acid" hypothesis was received with some scepticism and retracted later,<sup>4</sup>it offered a reasonable explanation for the nucleic acid-induced resistance to viral infection, which had been described<sup>5</sup>as early as 1953. Moreover, it raised a possible explanation for the antiviral action of agents such as bacteria or apparently nonviral agents as the mold products statolon (culture filtrate of<i>Penicillium stoloniferum</i>) and helenine (mycelium extract of<i>Penicillium funiculosum</i>) which had been found active in a number of experimental viral infections.<sup>6-13</sup>
status: Published
The paper describes the experiences with a Belgian Primary Care data Network from 1999 till 2002. Three cycles of data collection have been performed. The network involves about 300 general practitioners (GPs) and up to 8 different software packages. This network is semi-anonymous, semi-automatic and mixed (paper and electronic with various software&rsquo;s). For the coming next years, efforts should be focused on solving some frequently occurring problems with the data collection through the EPR, such as a considerable number of data lacking and the fact that GPs do not always use the problem oriented structure of the EPR (Electronic Patient Record). Afterwards, more promising usage could be considered and developed such as repeated data collection using a same GPs &lsquo; sample, long term recording studies, usage of larger GPs&rsquo; samples, etc.
