Publications

Ever since composite materials where first introduced, they have been pushing the boundaries of high performance, lightweight designs in all branches of engineering. The demand for sustainable lightweight structures results in an augmented use of thermoplastic composites. Depending on the type of matrix and reinforcement, there are various manufacturing options for the fabrication of composite parts. Composite manufacturing processes are in essence additive processes. In order to reduce the labor-intensive manual operations, and the need for a flexible automated composite process, researchers are investigating the feasibility of implementing Additive Manufacturing (AM) techniques to aid the fabrication of composite parts. AM techniques are able to produce parts directly from CAD data sources. As opposed to classical subtractive fabrication methods, parts are created layer upon layer. The geometric freedom provided by the additive process unlocks a wide variety of designs, which would be impossible to create via subtractive methods. Furthermore, AM processes have no direct need of tooling. The flexibility of this manufacturing approach gives rise to the development of application-oriented parts. Given the flexibility of the additive process, these techniques can be used in the design and manufacturing of composite parts. There are several options for which AM can be implemented in the composite production process. This paper highlights the potential of AM in the design and manufacturing of composite parts, gives a review on the application of composite AM, and identifies the technological challenges associated with the direct production of thermoplastic AM composites.

Abstract No antiviral activity or cytotoxic effects are detected for the novel tiazofurin aza‐analogue (XI) as well as its hydrazide and hydroxylamide analogues.

This paper presents a performance evaluation test for laser line scanners on 3D coordinate measuring machines (CMMs). Laser line scanners are becoming more popular in recent years, mainly for free form inspection tasks and reverse engineering. Error specification of these scanners is difficult because of many influencing factors like surface quality, surface orientation and scan depth. Therefore, procedures for evaluation and verification of conventional contact probes (e.g. touch-trigger probes) are not appropriate for non-contact laser line scanners. A straightforward test method that uses a planar test artefact is proposed. It enables to identify the influence of in-plane and out-of-plane angle, as well as scan depth on systematic and random errors of the laser scanner. Experimental results show that the tested commercial laser scanner, after calibration, exhibits systematic errors of about 10 μm.

Abstract Reaction of 1-[2,5(and 3,5)-di-O-trityl-β-D-erythro-pentofuran-3 (and 2)-ulosyl]uracil derivatives 5 and 6 with (chloromethyl)triphenylphosphorane resulted in the stereoselective formation of (E)-3′- and (Z)-2′-chloromethylene derivatives 7 (69%) and 8 (53%), respectively, deprotection of which gave 9 and 10. Transformation of the uracil nucleoside 7 into cytosine one followed by deprotection yielded 12. The latter was converted into the arabinoside 14. The fully deprotected chloromethylene nucleosides were tested for their activity against HIV-1 and HIV-2.

A series of novel 2′-deoxyuridines with a thienyl substituent in the 5-position were synthesized as potential anti-HSV-1 agents. The brominated derivatives (1d, 1e and 3b) were obtained via halogenation reactions of the protected 5-(thien-2-yl)-2′-deoxyuridine and 5-(thien-3-yl)-2′-deoxyuridine, respectively. The palladium-catalysed cross-coupling reaction with stannylated thiophene was used for the synthesis of ( E)-5-(2-thienylvinyl)-2′-deoxyuridine and 5-(5,2′-dithien-2-yl)-2′-deoxyuridine. These compounds show moderate to good activity against herpes simplex virus type 1 (HSV-1) in the order of decreasing activity 1d>4>1e>3b∼5. Finally, two substituted 5-isoxazol derivatives of 2′-deoxyuridine (6a and 6b) were obtained via a 1,3-dipolar cycloaddition of the protected 5-ethynyl-2′-deoxyuridine. These new compounds demonstrated poor affinity for the virus-specific enzyme thymidine kinase.