Publications

Phase separation and conductivity studies on the interaction of promethazine hydrochloride drug with cationic and nonionic surfactants: influences of electrolytes and temperature

Erratum to “Novel Facial Conducting Polyamide-Based Dithiophenylidene Cyclyhexanone Moiety Utilized for Selective Cu²⁺ Sensing”

The present work is aimed to synthesize a novel series of linear polyamides (PAs) 4a–d based on di(thiazolyl-thiophenylidene)cyclyhexanone as well as carries aliphatic and aromatic species in the polymer main backbones. The polymerization process was occurred by solution polycondensation technique by the interaction of the newly synthesized monomer 3 with adepoyl, sebacoyl, terphthaloyl, and isophthaloyldiacid chlorides. Before polymerization, the structure of monomer 3 was confirmed by elemental and spectral analyses. The structures of polymers were also investigated by elemental, spectral analysis, thermal analysis, and Field-Emission Scanning Electron Microscopy (FE-SEM) micrographs. Film draw temperatures for all the polymers were evaluated in the range 509.0–542.3°C. Here, the heavy metallic sensors are developed with the polyamide-fabricated glassy carbon electrode (GCE) by reliable current vs. voltage technique. A thin layer of PA onto GCE was fabricated with conducting coating agents (5% nafion) to fabricate a selective heavy metal ions, Cu2+ sensor in short response time in phosphate buffer phase. The fabricated sensor was also exhibited higher sensitivity, lower detection limit, large dynamic concentration ranges, long-term stability, and improved electrochemical performances toward Cu2+ sensor. The calibration plot is linear (r2: 0.9956) over the large Cu2+ ion concentration ranges (1.0 nM to 10.0 mM). The sensitivity and detection limit is 3.4177 µA cm−2 µM−1 and 0.36 nM (signal-to-noise ratio of 3) respectively. This novel effort is initiated a well-organized way of efficient cationic sensor improvement with conductive polymers for heavy metallic pollutants in environmental and health-care fields in large scales.

Core–shell cobalt oxide mesoporous silica based efficient electro-catalyst for oxygen evolution

Water splitting at low overpotentials using a plausible self-repair electrocatalyst based on Co₃O₄ nanomaterials.

CCDC 1018979: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.

Palladium (II) Complexes Containing 2-Phenylpyridine Derivatives: Synthesis, Molecular Structures, and Catalytic Activity for Suzuki–Miyaura Cross-Coupling Reactions

The preparation and characterization of a series of new 2-phenylpyridine derivative ligands consisting of 2-(R) pyridine (R = mesityl (L1), 2,6-dimethylphenyl (L2), o-tolyl (L3), m-tolyl (L4), p-tolyl (L5), o-methoxyphenyl (L6), and p-methoxyphenyl (L7)) and their Pd complexes [PdCl2L2] (L1–L7) is investigated using a combination of X-ray diffraction spectroscopy, GC-MS, and NMR. The crystal structures show that the Pd complexes adopt a square planar geometry, and the monodentate ligand is coordinated through the N donor of the pyridine ring to the Pd atom. The catalytic activities of the synthesized complexes are investigated. The square planar Pd complex trans-[(2-mesitylpy)2PdCl2)] shows a high efficiency in promoting Suzuki-Miyaura cross coupling in an aqueous solvent under aerobic conditions.

Metabolomics profiles associated with SARS-CoV-2 -IgG serostatus as an alternative diagnostic approach

Our findings identify metabolomic alterations associated with SARS-CoV-2 infection between IgG-positive and IgG-negative individuals. The identified metabolites are involved in regulating lipid metabolism, immune response, and the inflammatory signaling pathways. The results offer preliminary hypothesis generating insights into the underlying changes that may inform future research on host-immune interactions in COVID-19. Changes in these metabolites need to be validated in larger and independent cohorts.

Multicentre randomised double-blinded placebo-controlled trial of favipiravir in adults with mild COVID-19

Introduction A novel coronavirus, designated SARS-CoV-2, caused an international outbreak of a respiratory illness, termed COVID-19 in December 2019. There is a lack of specific therapeutic agents based on evidence for this novel coronavirus infection; however, several medications have been evaluated as a potential therapy. Therapy is required to treat symptomatic patients and decrease the virus carriage duration to limit the communitytransmission. Methods and analysis We hypothesise that patients with mild COVID-19 treated with favipiravir will have a shorter duration of time to virus clearance than the control group. The primary outcome is to evaluate the effect of favipiravir on the timing of the PCR test conversion from positive to negative within 15 days after starting the medicine. Adults (>18 years, men or nonpregnant women, diagnosed with mild COVID-19 within 5 days of disease onset) are being recruited by physicians participating from the Ministry of National Guard Health Affairs and the Ministry of Health ethics committee approved primary healthcare centres. This double-blind, randomised trial comprises three significant parts: screening, treatment and a follow-up period. The treating physician and patients are blinded. Eligible participants are randomised in a 1:1 ratio to either the therapy group (favipiravir) or a control group (placebo) with 1800 mg by mouth two times per day for the first day, followed by 800 mg two times per day for 4–7 days. Serial nasopharyngeal/oropharyngeal swab samples are obtained on day 1 (5 days before therapy). On day5±1 day, 10±1 day, 15±2 days, extra nasopharyngeal/oropharyngeal PCR COVID-19 samples are requested. The primary analysis population for evaluating both the efficacy and safety outcomes will be a modified intention to treat population. Anticipating a 10% dropout rate, we expect to recruit 288 subjects per arm. The results assume that the hazard ratio is constant throughout the study and that the Cox proportional hazard regression is used to analyse the data. Ethics and dissemination The study was approved by the King Abdullah International Medical Research Centre Institutional Review Board (28 April 2020) and the Ministry of Health Institutional Review Board (1 July 2020). Protocol details and any amendments will be reported to https://clinicaltrials.gov/ct2/show/NCT04464408 . The results will be published in peer-reviewed journals. Trial registration number National Clinical Trial Registry ( NCT04464408 ).

Structural and photophysical investigation of single-source evaporation of CsFAPbI₃ and FAPbI₃ perovskite thin films

Single source vacuum deposition is a stimulating technique for upscaling perovskite solar cells.

Synthesis and characterization of a novel series of benzenesulfonylurea and thiourea derivatives of 2H-pyran and 2H-pyridine-2-ones as antibacterial, antimycobacterial and antifungal agents

Arylhydrazines reacted with dehydroacetic acid (1) to give the corresponding 2H-pyran-2-one hydrazones (2), which on treatment with hydrazine hydrate afforded the corresponding 1-amino-2H-pyridin-2-ones (3). Reaction of 3 with nitrous acid, aromatic aldehyde and substituted benzenesulfonyl chlorides yielded the corresponding 2H-pyridine-2-one derivatives. A series of urea and thiourea derivatives were also prepared. Some of these compounds have shown significant antibacterial and mild to moderate antimycobacterial and antifungal activities.

Design, synthesis, anticancer activity and molecular docking studies of new benzimidazole derivatives bearing 1,3,4-oxadiazole moieties as potential thymidylate synthase inhibitors

Compounds 10 and 14 arrest the cell cycle at the G1 phase and induce apoptosis without any necrosis in MDA-MB-231 cells.

Photocatalytic, anti-bacterial performance and development of 2,4-diaminophenylhydrazine chemical sensor probe based on ternary doped Ag·SrSnO₃ nanorods

Ag·SrSnO₃ NRs is an excellent photocatalyst, kills both Gram positive and Gram negative bacteria. The 2,4-DAPHyd sensor fabricated by layered Ag<bold>·</bold>SrSnO₃ NRs onto GCE shows high sensitivity (7.5854 μA μM⁻¹ cm⁻²); LDR, 0.1 nM~0.01 mM &amp; LOD, 96.13 ± 4.81 pM.

Molecular insights into the role of fulvic acid in cobalt sorption onto graphene oxide and reduced graphene oxide

Development and characterization of the composites based on mesoporous MCM-41 and polyethylene glycol and their properties

Surface, micellar, and thermodynamic properties of antidepressant drug nortriptyline hydrochloride with TX-114 in aqueous/urea solutions

This paper deals with a comprehensive study of the mixed micellization and adsorption behavior of mixed systems enclosing an amphiphilic antidepressant drug nortriptyline hydrochloride (NOT) and Triton X-114 (TX-114) (nonionic surfactant) in aqueous/urea (500 mmol·kg−1 and 1000 mmol·kg−1) solutions by tensiometric method. The NOT is used for the cure of depression. For comparison purpose cmc value of pure drug NOT was also evaluated by conductimetric technique. Different theoretical models like Clint, Rubingh, and Rosen were used to get information about the nature of interaction between the components in bulk and at the interface. Because of the occurrence of urea increase in the surface charge of the micelles was obtained resulting a delay of the micelles formation. The cmc values of the mixed systems of NOT and TX-114 were found to be in between the cmc values of pure components, which signify nonideal mixed system having attractive interactions in the absence and presence of urea. Various parameters such as micellar mole fractions of TX-114 (X1m, X1σ) in solution and at interface, interaction parameter (βm/βσ) in solution and at interface, and activity coefficient in solution and at interface were evaluated and discussed using Rubingh's and Rosen's models. Surface excess (Γmax) increases that means minimum area per head group (Amin) decreases as mole fraction (α1) of TX-114 increases in the absence/presence of urea. Different thermodynamic parameters have been calculated and discussed. The ∆G0m values achieved are all negative both in the absence and occurrence of urea.

PHOTOCHROMIC PROPERTIES OF (E)-DICYCLOPROPYLMETHYLENE-(2,5-DIMETHYL-3-FURYLETHYLIDENE)-SUCCINIC ANHYDRIDE DOPED IN POLYSTYRENE THIN FILMS

DATA ANALYSIS AND EVALUATION OF THE ELECTROCHEMICAL PARAMETERS FOR THE ET PROCESS VIA CONVOLUTIVE VOLTAMMETRY AND DIGITAL SIMULATION

Data treatment and determination of the standard heterogeneous rate constant of simple ET process (simple electron transfer) & number of electrons consumed in electrode reaction were carried out via convolution-deconvolution voltammetry and digital simulation methods. The working curves required for determination of the standard heterogeneous rate constant, k s , were constructed and discussed. The number of electrons, n, consumed in electrode reaction was calculated via simple method. The electro-reduction of Pb 2+ was carried out at hanging mercury drop electrode while the redox behaviour of Fe 3+ /Fe 2+ couple was performed at glassy carbon electrode to confirm the validity of the reported method in calculation of k s and n in case of simple ET.

Novel and Sensitive Ethanol Chemi-Sensor Based on Nanohybrid Materials

Environmental pollution is one of the global hot issues and need an urgent demand to detect and monitor the pollutants which affect the environment. Ethanol is one of the organic pollutants which cause severe harmful effect on environment due to its toxic nature. For the detection and quantification of organic pollutants, sensors are the promising and reliable technology which has vital role in the environmental and health monitoring. A lot of sensor materials have been exposed but the prospective for industrial development as sensors and environmental supplement are still limited due to its non eco-friendly nature. Therefore, environmental friendly and biodegradable ethanol chemical sensors have been fabricated by efficient utilization of poly propylene carbonate (PPC) and PPC/silica hybrid (H) for the detection and quantification of ethanol in the environment. PPC/silica hybrid membrane has been synthesized by intercalation of silica into PPC matrix using a sol-gel technique. The resulting membrane was characterized by Fourier transform infrared spectroscopy (FTIR), while the morphology of the hybrid was investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). Both PPC and H performed as best ethanol chemi-sensor in term of sensitivity. Hybrid membrane showed 2.08 times higher sensitivity (0.5698 μA.cm-2.mM-1) than pure PCC (0.2534 μA.cm-2.mM-1). Hybrid membrane also displayed 3.1 times lower limit of detection (LOD, 20.70 μM) than pure PCC (64.29 μM). Therefore, hybridization is an efficient route to fabricate proficient aqueous ethanol sensor.

CCDC 786545: Experimental Crystal Structure Determination

An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.