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An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Herein, we have examined the interaction between promazine hydrochloride (PMZ) with bile salts (sodium cholate (NaC) and sodium deoxycholate (NaDC)) at different temperatures and compositions using conductometric method. The critical micelle concentration (cmc) value of pure PMZ and bile salts were also evaluated by tensiometric method. The cmc values attained by the two methods are close to each other. Various physicochemical parameters like cmc, ideal cmc (cmcid), degree of dissociation of counterion (g), micellar mole fractions of bile salt (, , ), micellar mole fraction of bile salt in ideal state (), interaction parameter (βm), activity coefficients (f1, f2), standard Gibbs free energy (), enthalpy (), entropy of micellization (), and excess free energy of mixing (ΔGex) of the mixed micelles have been evaluated and discussed in detail using Clint's, Rubingh's, Motomura's, and Rodenas's models. NaDC is more efficient in decreasing the cmc of PMZ as compared to NaC because it binds strongly to PMZ ions and more decreases the head group area of drug. On the whole, this lesson might find application in the fundamental science of the physical chemistry of amphiphilic systems, as well as in the research of drug delivery system.
Confinement of Au nanoparticles (NPs) within the porous materials with few nanometers (2-3 nm) has been a well established research area in the past decades in heterogeneous catalysis mainly due to the unique behaviour of Au NPs than its bulk counterpart. In this aspect, Au NPs encapsulated within the pore volumes of metal-organic frameworks (MOFs) have been intensively explored as heterogeneous solid catalysts for wide range of reactions. In recent years, Au NPs confined within the porous MOFs along with the photosensitizer or drug have been effectively used for the treatment of tumor cells through the generation of reactive oxygen species via cascade reactions. This work highlights the benefits of MOFs pores in the preparation of nanomedicine with high efficiency by assembling Au NPs, photosensitizer/drug with the combination of laser either for imaging or treatment of tumor cells. Further, the existing literature is grouped based on the nature of porous materials employed in the preparation of nanomedicine. The final section comments on our view on future developments in the field.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Herein, the interactions between the sodium salt of ibuprofen (IBU) with nonionic surfactant-BRIJ-56 were investigated at the interface as well as in the bulk phase (solution) in the existence and nonexistence of urea (250 mM). In the present study, tensiometric and fluorometric techniques have been utilized to investigate the association and micro-environmental properties of mixed systems. Various models (such as Clint, Rubingh, Maeda, etc.) were employed to obtain information regarding the nature of interaction between the components in bulk as well as at the interface. The critical micelle concentration (cmc) of pure amphiphiles and their mixed system increases in the existence of urea due to enhancement in the surface charge of the micelles. The urea activities have been explored on account of diverse aspects, such as the salvation of head groups and hydrophobic interactions. The aggregation number, micropolarity, and apparent dielectric constant of pure and mixed systems were investigated using steady-state fluorescence spectroscopy. A variety of energetic parameters (for instance the standard Gibbs free energy of micellization, Gibbs free energy of adsorption, and Gibbs excess energy) have been evaluated for further insight of urea action. The Δ values achieved are all negative, both in the absence and in the presence of urea.
