2,859 publications from this institution
The 1,3-dipolar cycloaddition reaction of the chalcones with azomethine ylide (generated by isatin and sarcosine) has been constructed to functionalize novel spiropyrrolidines. The synthesized compounds (4a–d) structures were characterized by modern spectroscopic techniques and further corroborated a compound 4a by single crystal X-ray study. The in vitro antibacterial activity of novel spiropyrrolidines was evaluated against the Gram-positive and Gram-negative bacterial strains Bacillus subtillis, Enterococcus faecalis and Escherichia coli, Pseudomonas aeruginosa, respectively. Among them, compound 4c was found the most potent antibacterial agent. The minimum inhibitory concentration (MIC) observed was 75 and 125 µg/mL against all targeted Gram-positive and negative strains respectively. Furthermore, the compounds were also explored for their inhibitory potential against a known therapeutic target and an essential bacterial enzyme, DNA gyrase using computational methods.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
Abstract: The title compound 2-[(3,5-dimethyl-1-phenyl-1 H -pyrazol-4-yl)methylene]-indane-1,3-dione ( 3) was synthesized in high yield by reaction of 3,5-dimethyl-1-phenyl-pyrazole-4-carbaldehyde and indane-1,3-dione in ethanol in the presence of pyridine. The structure of this new compound was confirmed by elemental analysis, IR, 1 H NMR, 13 C NMR and GC-MS spectral analysis. Keywords: Knoevenagel condensation; indane-1,3-dione; pyridine Naturally occurring as well as synthetic pyrazole-containing heterocyclic compounds have great importance for their biological activities such as anti-bacterial [1], anti-inflammatory [2], anti-hypertensive [3], anti-cancer [4], and anti-amoebic activity [5]. Pyrazole-containing donor-acceptor chromophores are also applicable in materials fields for their properties such as non-linear optical (NLO), optical limiting [6], electrochemical sensing [7] and langmuir film [8]. Due to the wide application of pyrazoles we decided to synthesize a new pyrazole-containing donor-acceptor chromophore by Knoevenagel condensation in analogy to a previously published procedure [9].
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
The inclusion of organometallic units into polymeric structures has attracted much attention in different fields according to the nature and behaviour of the inserted metal. Moreover, the discovery of organometallic polymers and their structural characterization initiated an explosive rebirth of organometallic chemistry. Organometallic moieties are in or pendent to the polymer backbone and examine some of the uses of the emergent metallocene polymers, and new uses are still being found for these remarkable organometallic moieties. This review gives a simple introduction to variable organometallic molecules and their characteristics. This review will focus on the syntheses and characterization of organometallic polymers, including ferrocene- and phosphorus-containing polymers. A general overview on ferrocene polymers with a special attention to ferrocene-containing liquid crystalline polymers (including a ferrocene moiety in the main chain, side-chain or dendrimers) and fullerene–ferrocene liquid crystalline polymers is presented. In addition, more details for synthesis and properties of phosphorus-containing polymers are illustrated.
Compound 3a crystallises as monoclinic, P2 (1)/a and 3b as P-1. The X-ray crystal structures reveal that asymmetric unit contains one independent molecule in 3a, whereas 3b exhibits a very interesting behavior in having a higher Z value of 8 and four independent molecules in its asymmetric unit. The molecular electrostatic potential (MEP) mapped over the entire stabilized geometries of the molecules indicates the potential sites for chemical reactivities. Furthermore, high first hyperpolarizability values entitle these compounds as potential candidates in photonic applications.Graphical abstractPhenothiazines; a comparison of experimental and theoretical analysis.
