Three new azomethine dyes were synthesized via a simple condensation method using 2-amino-4,5,6,7-tetrahydro-benzo[b]thiophene-3-carbonitrile and a variety of aldehydes. The structures of synthesized compounds were established by spectroscopic (FT-IR, 1H NMR, 13C NMR, MS) and elemental analyses. UV-Vis and fluorescence spectroscopy measurements proved that all compounds have good absorbance and fluorescence properties. Fluorescence polarity studies demonstrated that these compounds were sensitive to the polarity of the microenvironment provided by different solvents. In addition, spectroscopic and physicochemical parameters, including singlet absorption, extinction coefficient, Stokes shift, oscillator strength and dipole moment, were investigated in order to explore the analytical potential of the synthesized compounds. Three-dimensional structures were studied using single crystal x-ray diffraction. Optimized geometries, electronic structure and frontier molecular orbital energies were studied theoretically, and the energy gap (ΔE) of II was found to be relatively greater than those for I and III, while I and III have almost the same energy gaps.
Quinolines have become essential to many drugs, including broad-spectrum antibiotics, antivirus, antitubercular, and antimalarial agents. Owing to their importance in medicinal and pharmaceutic industries, several studies have been conducted to synthesize new and novel quinoline derivatives and their hybrid compounds with potent biological applications. In this review, we report the recent research involved in the search for biologically active molecules containing quinoline moiety, including their hybrids. The review provides information on advancements in the last ten years in the chemistry of hybrids and derivatives of quinolines. Also, the medicinal impact of some potent patents based on quinoline derivatives is discussed
A novel approach for topological analysis of molecular packings is described and tested on the crystal structures of sulfonamides.
Various oxime-ether derivatives of cholesterol have been synthesized by the alkylation of the steroidal oxime with 1-(2-chloroethyl) pyrrolidine hydrogen chloride/chloroethylamine hydrochloride in the presence of sodium methoxide in dry methanol. The structures of these compounds were elucidated by IR 1H NMR, FAB mass spectroscopic methods and elemental analyses. The anti-bacterial activity was first tested in vitro by the disk diffusion method against two Gram-positive and two Gram-negative bacteria, and then the minimum inhibitory concentration (MIC) of compounds were determined. The results showed that the chloro derivatives exhibited better anti-bacterial activity than the standard drug chloramphenicol.
Humidity is the presence of water vapor in the air. In view of its effect on human health and the physical qualities of materials, humidity must be measured and controlled. Humidity measurement is imperative in a variety of fields including health care, environmental monitoring, automobiles, air-conditioning, civil engineering, agriculture, semiconductors, pharmaceuticals, textiles, paper and processing industries. This book provides an overview of humidity and the types and applications of humidity sensors. This book will be helpful for students, researchers and general readers.
