Publications

Pyridazines are organic compounds in which benzene has nitrogen atoms instead of two carbon atoms. The pyridazine structure is one of the heteroaromatic rings that can be developed for drug design. Pyridazinone analogues are found in the structure of drugs with different activities. This core is of interest to medicinal chemists because of its diverse pharmacological activities. In this review, some of the antibacterial and antifungal, analgesic and anti-inflammatory, anticancer, cardiovascular and anticholinesterase compounds with pyridazinone structure are mentioned.

High temperatures negatively affect the mechanical properties of concrete. This study examines the effect of elevated temperature on the mechanical properties of concrete produced with raw perlite aggregate. In the research, high temperature tests (25°C, 200°C, 400°C, and 600°C) were conducted on four different concrete mixtures (C25, C40, P25, and P40) produced using two different aggregate types (raw perlite aggregate and conventional coarse aggregate). Experimental results showed that as the temperature increased to 600°C, the compressive strength of conventional concrete samples decreased by 34.91% for C25 and 41.79% for C40, while the raw perlite aggregate samples (P25 and P40) exhibited significantly lower strength reductions of only 9.91% and 12.80%, respectively. These findings clearly demonstrate that raw perlite aggregate significantly enhances thermal resistance compared to conventional aggregates. Additionally, although the flexural strength of P25 and P40 samples at 25°C was initially lower due to the more limited stress-strain relationship of perlite, their post-exposure performance showed similar flexural behavior under increasing temperature. Microstructural analyses further confirmed that raw perlite aggregates contribute to minimizing micro-crack propagation and are more resistant to thermal degradation. In conclusion, raw perlite aggregate provides a sustainable and economical alternative for fire-resistant structures.

Many researches have been done to investigate using raw materials in the production of geopolymer cements. The aim of this paper is the effect of dosage of alkali and silica modulus when using sodium metasilicate solution at different curing conditions on the geopolymerisation of ferrochrome slag (FS). As alkali activation for geopolymerization, NaOH and Na <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> solution were used. Geopolymer cement was produced using FS and 3 different silica modulus (0.50, 0.60, and 0.70) and 4 different Na <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O concentrations (4, 7, 10, and 12%). The setting time, heat of hydration and compressive strength of geopolymer paste samples and compressive strength of geopolymer mortar samples were obtained. The setting time varies between 120 and 870 min, it shows variability depending on content of Na <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O. As a result of the highest 28 day strength of the geopolymer paste sample was obtained at Na <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> O concentration of 7% and at silica modulu of 0.70. Geopolymer mortars were prepared for the determination of compressive strength by adding FS:sand:alkali activator ratio 1∶2∶0.30, 0.35 and 0.40. The specimens were cured at 60°C, 80°C kept in 20 hours and the other mortars were stored under laboratory conditions. Compressive strength of the material decreases, when w/b ratio increases. The highest 28 day strength of the geopolymer mortar was obtained at 0.30 w/b ratio and at curing temperature laboratory conditions. The hydration heat of geopolymer paste samples was found to be less than normal Portland cements. Microstructural changes in the specimens were studied with SEM and XRD.

Nafimidone and nafimidone alcohol, which were synthesized in 1981 and whose anticonvulsant activities were determined, are important anticonvulsant compounds in the structure of (arylalkyl)azole, which reached the stage of clinical human studies but could not pass this stage. In this study, the commercially available chiral stationary phase amylose tris(3,5-dimethyphenylcarbamate) (Chiralpak AD) was used to establish direct enantiomeric separations of nafimidone alcohol which is the methabolite of nafimidone in the normal phase HPLC mode. Investigations were also done into the compositional influences of the mobile phase. When the mobile phase was switched from methanol to n-hexane, the retention times were shortened. The mobile phase of methanol/n-hexane (70:30 v/v) at a flow rate of 0.2 mL/min produced the best results, with an enantiomer resolution of 0.83. Consequently, further chemical and pharmacological research on nafimidone alcohol and its enantiomers can be facilitated by the proposed HPLC approach.

Abstract Background Heart failure (HF) poses a significant burden on global healthcare systems, necessitating effective therapeutic interventions. Vericiguat, a novel agent targeting soluble guanylate cyclase, has emerged as a potential treatment for HF. Purpose To understand its impact on patient outcomes, including safety, tolerability, and quality of life (QoL). Methods A comprehensive meta-analysis was conducted, encompassing four randomized controlled trials (RCTs) identified through Cochrane CENTRAL, Ovid Medline R, Pubmed, and Web of Science databases up to December 1, 2023. The primary efficacy outcome, Kansas City Cardiomyopathy Questionnaire (KCCQ) Overall Summary Score (OSS), and the primary safety outcome, drug-related serious adverse events (AEs), were analyzed. Pooled mean differences (MD) and risk ratios (RR) were calculated using inverse variance common-effect model. Results The meta-analysis encompassed 5947 patients across the four RCTs. Our findings indicated that vericiguat did not demonstrate a significant beneficial effect on KCCQ-OSS (MD -0.13, 95% CI -1.32 to 1.05), suggesting no substantial impact on overall QoL, despite a statistically significant improvement in the KCCQ-Physical Limitation Score (PLS) (MD 3.74, 95% CI 0.24 to 7.24) compared to placebo. Notably, vericiguat exhibited a favorable safety and tolerability profile, with comparable risk for AEs leading to death (RR 1.32, 95%CI, 0.58 to 3.03), withdrawal due to AEs (RR 1.08, 95% CI 0.88 to 1.32) or serious AEs (RR 1,18, 95%CI, 0,50; 2,80), renal and urinary disorders (RR 0.99, 95% CI 0.88 to 1.11), symptomatic hypotension (RR 1.17, 95% CI 0.98 to 1.40), and acute kidney injury (RR 1.04, 95% CI 0.83 to 1.31) compared to placebo. Conclusion Vericiguat demonstrates promising safety and tolerability profiles in patients with HF. While our analysis reveals significant improvement in KCCQ-PLS, indicating enhanced physical limitation scores, the lack of statistically significant impact on overall QoL raises questions about its comprehensive efficacy. These findings underscore the need for further research to elucidate the holistic impact of vericiguat on patient-reported outcomes in heart failure management.Forest plot of quality of life outcomesForest plot of safety outcomes

Abstract New materials are investigated with the development of technology. Therefore, gathering materials of different qualities is necessary to achieve such a goal. Two or more materials formed by combining materials, called composite, are used in many areas of life. In this study, the internal failure pressure of a glass fiber composite pipes reinforced with aramid fiber, which is not documented in the literature, was investigated. In this direction, the composite pipes produced with different variations were subjected to testing. The prepared composite pipes consisted of four layers. Firstly, the test was carried out for pipes where all the layers were made of glass fiber. Secondly, it was repeated for pipes with one of the intermediate layers of aramid fibers. In the next experiment, the layer location of the aramid fiber was changed. Finally, composite pipes with two intermediate layers of aramid fiber were tested. Damage pressures of composite pipes produced by four different types were compared. As a result, the lowest damage pressure was obtained from samples with glass fiber while the highest amount was obtained from two layers of glass fiber and two layers of aramid fiber.

Compressive strength and UPV parameters are the methods that are used to determine high-volume mineral admixture concrete quality. But experiments for all levels of these parameters are expensive, difficult and time consuming. For determination of output values, classifiers with model extraction features can be used. In this study, classifiers, with the rule-based M5 rule and tree model M5P in the area of data mining are used to predict the compressive strength and UPV of concrete mixtures after 3, 7, 28 and 120 days of curing. The M5 rule and tree model M5P are tested using the available test data of 40 different concrete mix-designs gathered from literature [1] . The input of the model is a variable data set corresponding to concrete mixture proportions. The findings of this study indicated that the M5 rule and tree model M5P models are sufficient tools for estimating the compressive strength and UPV of concrete. 97% and 87% success is obtained in predicting compressive strength and UPV results, respectively.

When the existing literature is examined, it can be seen that many studies have been carried out to improve the mechanical properties of concrete by using waste or additive materials with different mechanical and physical properties in various proportions instead of the conventional aggregate used in concrete production. Within the scope of this study, it was aimed to examine the physical and mechanical properties of the samples fabricated using natural perlite aggregate instead of conventional aggregate by exposing them to high temperature effects. In this context, a total of 96 concrete samples will be fabricated, including 48 rectangular prism beams with dimensions of 10x10x40 cm and 48 cube samples with dimensions of 15x15x15 cm, with a concrete compressive strength of 25 and 40 MPa, using perlite and conventional concrete. The samples were planned to be exposed to temperature effects of 200ºC, 400ºC and 600ºC at room temperature. Afterwards, the samples will be examined with destructive/non-destructive methods such as mass loss (ML), ultra sound transmission rate (USTR), compressive strength (CS), elasticity modulus (EM)and pure bending (PB) test, and the mechanical and physical properties of all samples will be compared.

The effect of high temperatures up to 700°C on compressive strength and water absorption of two alkali-activated aluminosilicate composites (one of them with river sand aggregates, the second crushed sand aggregates) and ordinary Portland cement (OPC) concretes is analyzed in this paper. Binding geopolymer material was obtained after grinding the Elazığ Ferrochrome slag (EFS) as fine as cement and alkaline activating with chemical materials (NaOH-Na <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">2</inf> SiO <inf xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink">3</inf> ). Geopolymer concrete samples were produced by using this binding material with aggregates. Produced concrete samples were exposed to temperature for 1 hour, after reaching the maximum temperature. Fire resistance and water absorption of geopolymer and OPC concrete samples was obtained experimentally. Compressive strength of river aggregates and crushed sand aggregates concrete increased at 100 and 300°C temperatures compared to unexposed samples, and the maximum compressive strength for these geopolymer concrete sample was obtained at 300°C. Water absorption of all concrete samples increased at 700°C temperature compared to unexposed samples. But there appeared to be a slight decrease of water absorption in the all concrete samples up to 300°C temperatures compared to unexposed samples. Scanning electron microscopy and XRD tests were also conducted to examine microstructure and mineralogical changes during the thermal exposure.

This paper describes a laboratory investigation of the resistance to freezing and thawing of Expanded Perlite Aggregate (EPA) concrete, compared with that of natural aggregate concrete. The effects of EPA ratios on High Strength Concrete (HSC) properties were studied for 28 days. EPA replacements of fine aggregate (0–2 mm) were used: 10%, 20% and 30%. The properties examined included compressive strength, Ultrasound Pulse Velocity (UPV), porosity, microstructure and the Relative Dynamic Modulus of Elasticity (RDME) of HSC. Results showed that the compressive strength, UPV and RDME of samples were decreased with an increase in EPA ratios. Test results revealed that HSC was still durable after 100, 200 and 300 cycles of freezing and thawing in accordance with the ASTM C666. After 300 cycles, reduction in compressive strength and RDME ranged from 7% to 29% and 5% to 21%, respectively. In this paper, feed-forward Artificial Neural Network (ANNs) techniques were used to model the relative change in compressive strength and UPV in cyclic thermal loading. Genetic algorithms were applied in order to determine optimum mix proportions subjected to 300 thermal cycling. The best performance was obtained from HSC with about 10% EPA.

Efforts to develop new potent and effective antimicrobial compounds with lower side effects are important not only for controlling serious infections but also for cancer, surgical operations, and preventing possible infections which are related to other threats.Therefore, it is getting more important to develop new antibacterial and antifungal compounds with wide spectrum, systemic effect and lower side effects.In this study eight new 3(2H)pyridazinone derivatives were synthesized and their antimicrobial activities were evaluated by using broth microdilution method agains two Gr (+) (Staphylococcus aureus, Enterococcus faecalis), two Gr (-) bacteria (Pseudomonas aeruginosa, Escherichia coli) and three yeasts like fungi (Candida albicans, Candida krusei).Compound D2a had the best antibacterial activity among the synthesized compounds.All compounds were more effective against the fungus than the bacteria.In this study, we performed molecular modelling studies to provide in depth understanding of their CYP51 inhibition.Antifungal susceptibility tests against standard Candida spp.including C. albicans revealed D2aas highly active compound.The molecular docking studies showed similarities in binding interactions in active site gorges of the enzymes with known inhibitors, such as VT1, fluconazole.