Publications

Extracellular Adenosine 5'-Triphosphate in Obstructive Airway Diseases

Essentials of Restenosis

Leading interventional cardiologists, including Patrick Serruys, Eric Topol, David Holmes, Thomas Luscher and others provide the gold-standard reference on the treatment of restenosis (coronary artery

Glucocorticosteroids in Asthma

Exhaled Nitric Oxide in Pulmonary Diseases

Discrete and continuous treatment of local buckling in stainless steel elements

MATERIAL PROPERTIES AND LOCAL STABILITY OF WAAM STAINLESS STEEL PLATES WITH DIFFERENT DEPOSITION RATES

Wire arc additive manufacturing (WAAM) has significant potential to produce freeform, but structurally efficient geometries out of stainless steel, for use in the construction industry, however, there is currently no standardisation of the manufacturing parameters used to produce WAAM structures. This paper discusses an experimental programme carried out on WAAM 316L stainless steel plated structures to assess the effects of the deposition rate, which is directly associated with productivity. This programme comprises tensile tests on coupons extracted along different printing directions, geometric imperfection measurement (including surface roughness, waviness and overall out-of-straightness), and stub column tests designed to determine the local stability of unstiffened plates manufactured with different deposition rates. The applicability of current Eurocode design rules for stainless steel structures, including the ductility requirements and effective width equations, have been assessed based on the obtained experimental data.

Impact of the Orbital Atherectomy System on a Peripheral Calcified Lesion

No abstract is provided for this article.

Localization and mode interaction in sandwich structures

Neuropeptides and Asthma

Editorial: Are inflammatory biomarkers following bioresorbable scaffold or drug-eluting stent implantation directly linked to outcomes?

No abstract is provided for this article.

Late stent thrombosis in drug-eluting stents: return of the 'VB syndrome'

No abstract is provided for this article.

Metabolism of 3H-arachidonic acid in male dog lung in vitro using a perfusion system designed to mimic physiological conditions.

ADVANCED ANALYSIS WITH STRAIN LIMITS FOR THE DESIGN OF STEEL STRUCTURES

Segmental post-PCI physiological gradients using ultrasonic or optical flow ratio

Background Segmental pressure gradients post percutaneous coronary intervention (PCI) may detect residual disease and potential targets for optimization. Ultrasonic flow ratio (UFR) or optical flow ratio (OFR) provide simultaneous physiological and morphological data using a single imaging catheter. Notably, both have been validated against wire based FFR Objectives To evaluate the utility of UFR and OFR to identify residual disease post-PCI. Methods The present study is a sub analysis of the ASET (Acetyl Salicylic Elimination Trial) JAPAN pilot study Phase I which showed the feasibility and safety of low dose prasugrel monotherapy following PCI in Japanese patients presenting with chronic coronary syndrome and an anatomical SYNTAX score <23. Patients with complete intra-vascular imaging pullback data were included with UFR/OFR acquired in all patients post-PCI. Quantitative and qualitative assessment of IVUS or OCT pullbacks was performed by automatically delineating vessel, lumen, and stent contours every 0.5 mm using QCU-CMS (version 4.69, Division of Image Processing, Leiden University Medical Centre). UFR or OFR was calculated using the respective IvusPlus or OctPlus software, Pulse Medical, Shanghai, China.(13)(15) All UFR and OFR tracings, and IVUS and OCT pullbacks were analyzed at the CORRIB Core lab, Galway, Ireland by two analysts blinded to clinical and procedural data. Anatomically focal lesions distal and proximal to the stent were evaluated in segments ≥5mm long. UFR/OFR virtual pullback curves were used to calculate intra-stent pressure gradients and physiologically define lesions as focal or diffuse by segmental pressure drops ≥0.05 over lengths <10mm or ≥10mm, respectively. Results The median post-PCI UFR/OFR was 0.93 (0.88-0.96) with 69/195 vessels (35.4%) having a UFR/OFR≤0.90. There were significantly more focal anatomical and physiological lesions proximal and distal to the stent in vessels with a UFR/OFR≤0.90 versus >0.90. In vessels with a UFR/OFR≤0.90 there was moderate agreement (weighted kappa=0.553, p<0.001) between anatomical and physiological focal lesions proximal to the stent, whilst it was fair (weighted kappa=0.219, p=0.002) distally. In-stent gradient had poor discriminative ability to detect significant stent under-expansion. The performance of a proximal or distal virtual FFR gradient to detect proximal or distal anatomically focal disease was good (AUC–0.835 and 0.877, respectively) Conclusions UFR/OFR enables suboptimal vessel physiology post-PCI to be detected and helps identify the precise anatomical location with corroboration from intra-vascular imaging. Adequately powered physiology optimization trials using UFR/OFR will determine the role of combined morphology and physiological evaluation post PCI in improving clinical outcomes.

Geometric imperfections in stainless steel cross-sections

Early detection of restenosis after successful percutaneous transluminal coronary angioplasty by exercise-redistribution thallium scintigraphy

The value of exercise testing and thallium scintigraphy in predicting recurrence of angina pectoris and restenosis after a primary successful transluminal coronary angioplasty (PTCA) was prospectively evaluated. In 89 patients, a symptom-limited exercise electrocardiogram (ECG) and thallium scintigraphy were performed 4 weeks after they had undergone successful PTCA. Thereafter, the patients were followed for 6.4 ± 2.5 months (mean ± standard deviation) or until recurrence of angina. They all underwent a repeat coronary angiography at 6 months or earlier if symptoms recurred. PTCA was considered successful if the patients had no symptoms and if the stenosis was reduced to less than 50% of the luminal diameter. Restenosis was defined as an increase of the stenosis to more than 50% luminal diameter. The ability of the thallium scintigram (presence of a reversible defect) to predict recurrence of angina was 66%, vs 38% for the exercise ECG (ST-segment depression or angina at peak workload). Restenosis was predicted in 74% of patients by thallium scintigraphy, but only in 50% of patients by the exercise ECG. Thus, thallium scintigraphy was highly predictive but the exercise ECG was not (p < 0.005). These results suggest that restenosis had occurred to some extent already at 4 weeks after the PTCA in most patients in whom it was going to occur.

Experimental study of swage-locking pinned aluminium alloy shear connections

FDA panel, 7 and 8 December 2006 - The impact on our practice and research.

No abstract is provided for this article.