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We appreciate the description by Mente et al. 1 of a dietary score comprised of fruits, vegetables, nuts, legumes, fish, and dairy foods that are inversely associated with adverse health outcomes.These findings align with other studies, including that associations are strongest in diets dominated by starchy staples typical of many low-income populations.In this context, modest amounts of animal-sourced foods can provide important nutritional value.However, the omission of harmful components in the dietary score, such as trans fat, high sodium, and sugary beverages, is a critical concern.Also, their implication that high intakes of red meat and dairy foods would be without adverse health consequences, especially if compared with plant protein sources, is inconsistent with considerable evidence. 2,3The diversity of the PURE populations is a strength, but in many of these populations, high intake of red meat is recent, and the experience of high-income countries shows that several decades of an atherogenic diet are needed to produce clinical disease (myocardial infarction before age 40 is rare).Also, within the PURE populations, marked variation in socio-economic status likely confounds some findings despite statistical adjustment.In addition, the range of many foods in their analysis was limited; for instance, in the top quintile of their score, intake of milk was only 186 g/day (one glass is ∼250 g), and most of this consumption was in the Americans and Middle East.Mente et al. misrepresent the Planetary Health Diet (PHD) as highly restrictive and low in legumes and fat; in fact, the PHD reference targets for milk equivalents (250 g/day) and legumes (75 g/day dry weight, excluding peanuts) exceed the top quintile of the PURE diet score. 4The targets for other animal-sourced foods provide approximately one serving per day, although red meat is about one serving per week.In the PHD nutritional analysis, total fat intake was 38% of energy, again higher than in PURE (27%), and intended to be flexible.Mente et al.'s scoring of the PHD was misleading because it used only the ranges for individual components, which describe the global variation that appears compatible with health.They ignored the target reference diet numbers, which provide a balanced dietary pattern within a given
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTKinetic resolution of unnatural and rarely occurring amino acids: enantioselective hydrolysis of N-acyl amino acids catalyzed by acylase IH. Keith Chenault, Juergen Dahmer, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1989, 111, 16, 6354–6364Publication Date (Print):August 1, 1989Publication History Published online1 May 2002Published inissue 1 August 1989https://doi.org/10.1021/ja00198a055RIGHTS & PERMISSIONSArticle Views4917Altmetric-Citations261LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (1 MB) Get e-AlertsSupporting Info (1)»Supporting Information Supporting Information Get e-Alerts
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ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTGlycerol kinase: synthesis of dihydroxyacetone phosphate, sn-glycerol-3-phosphate, and chiral analogsDebbie C. Crans and George M. WhitesidesCite this: J. Am. Chem. Soc. 1985, 107, 24, 7019–7027Publication Date (Print):November 1, 1985Publication History Published online1 May 2002Published inissue 1 November 1985https://pubs.acs.org/doi/10.1021/ja00310a045https://doi.org/10.1021/ja00310a045research-articleACS PublicationsRequest reuse permissionsArticle Views842Altmetric-Citations93LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The influence of material strain-rate dependence on necking retardation is studied. A relatively small amount of strain-rate dependence is known to lead to substantially increased straining prior to necking. Criteria based on linearized stability analyses do not reveal this behavior. A nonlinear analysis for long-wavelength nonuniformities does reproduce the essential details of the phenomenon. Limitations of the analysis are discussed.
Earthquake nucleation and early seismic propagation are studied in a two‐dimensional strike‐slip fault model with depth‐variable properties. The fault is governed by the Dieterich‐Ruina rate and state friction law. We use an efficient and rigorous numerical procedure for elastodynamic analysis of earthquake sequences on slowly loaded faults developed by Lapusta et al. [2000] . We find that for decreasing values of the characteristic slip distance of the friction law, small events appear at the transition from the locked to creeping behavior toward the bottom of the seismogenic zone. Small and large events have very similar nucleation phases in our simulations. Here, by “nucleation phase” we mean gradually accelerating aseismic slip in a small slowly expanding zone before the breakout of the dynamic, seismically detectable event. Moment acceleration (to which velocity seismograms are proportional) in early stages of seismic propagation exhibits irregular fluctuations, in the form of speedups and slowdowns in the moment release rate, consistently with observations as reported by Ellsworth and Beroza [1995] . Our simulations show that such irregular moment acceleration can, at least in part, be due to the heterogeneous stress distribution imprinted on the fault by the arrest of previous small events and by stress concentrations at the borders of creeping regions and to partial arrest of the rupture in velocity‐strengthening fault regions which inhibit seismic slip.
