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Scope The plasma metabolomics profiles of protein intake have been rarely investigated. The aim is to identify the distinct plasma metabolomics profiles associated with overall intakes of protein as well as with intakes from animal and plant protein sources. Methods and results A cross‐sectional analysis using data from 1833 participants at high risk of cardiovascular disease is conducted. Associations between 385 identified metabolites and the intake of total, animal protein (AP), and plant protein (PP), and plant‐to‐animal ratio (PR) are assessed using elastic net continuous regression analyses. A double 10‐cross‐validation (CV) procedure is used and Pearson correlations coefficients between multi‐metabolite weighted models and reported protein intake in each pair of training‐validation datasets are calculated. A wide set of metabolites is consistently associated with each protein source evaluated. These metabolites mainly consisted of amino acids and their derivatives, acylcarnitines, different organic acids, and lipid species. Few metabolites overlapped among protein sources (i.e., C14:0 SM, C20:4 carnitine, GABA, and allantoin) but none of them toward the same direction. Regarding AP and PP approaches, C20:4 carnitine and dimethylglycine are positively associated with PP but negatively associated with AP. However, allantoin, C14:0 SM, C38:7 PE plasmalogen, GABA, metronidazole, and trigonelline (N‐methylnicotinate) behave contrarily. Ten‐CV Pearson correlation coefficients between self‐reported protein intake and plasma metabolomics profiles range from 0.21 for PR to 0.32 for total protein. Conclusions Different sets of metabolites are associated with total, animal, and plant protein intake. Further studies are needed to assess the contribution of these metabolites in protein biomarkers’ discovery and prediction of cardiometabolic alterations.
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEnzymic conversion of .alpha.-keto aldehydes to optically active .alpha.-hydroxy acids using glyoxalase I and IIMark A. K. Patterson, Richard P. Szajewski, and George M. WhitesidesCite this: J. Org. Chem. 1981, 46, 23, 4682–4685Publication Date (Print):November 1, 1981Publication History Published online1 May 2002Published inissue 1 November 1981https://pubs.acs.org/doi/10.1021/jo00336a011https://doi.org/10.1021/jo00336a011research-articleACS PublicationsRequest reuse permissionsArticle Views286Altmetric-Citations37LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStereochemistry of the conjugate addition of derivatives of endo-2-norbornylcopper(I) to mesityl oxideGeorge M. Whitesides and Philip E. KendallCite this: J. Org. Chem. 1972, 37, 23, 3718–3725Publication Date (Print):November 1, 1972Publication History Published online1 May 2002Published inissue 1 November 1972https://pubs.acs.org/doi/10.1021/jo00796a032https://doi.org/10.1021/jo00796a032research-articleACS PublicationsRequest reuse permissionsArticle Views256Altmetric-Citations36LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts
The use of cofactor-requiring enzymes as catalysts for large-scale requires efficient and economical procedures for in situ regeneration of these cofactors. This manuscript summarizes the procedures which are now available for cofactor preparation and regeneration. ATP can be effectively regenerated from ADP (and AMP) using acetyl phosphate and acetate kinase (and adenylate kinase), and it can be prepared inexpensively from RNA. Use of ATP-requiring enzymes is now routine (at least as far as the ATP regeneration is concerned). The use of the nicotinamide cofactors is more difficult, because these materials decompose in solution. The best procedure for regenerating NAD(P)H from NAD(P)+ are those based on formate/formate dehydrogenase, glucose 6-phosphate/glucose-6-phosphate dehydrogenase, and ethanol/alcohol dehydrogenase/aldehyde dehydrogenase. The best procedures for regenerating NAD(P)+ from NAD(P)H use dioxygen/methyl viologen or ketoglutarate/glutamic dehydrogenase.
We discuss theoretical models of interfacial embrittlement by solute segregation. Of properties susceptible to alteration by segregation, the ideal work of interfacial separation, 2γ int, is predicted to have an important but probably not exclusive role in controlling embrittlement. A thermodynamic framework for estimating 2γ int from data available through free surface and grain boundary adsorption studies is outlined, and relevant segregation energies are given for carbon, phosphorus, tin, antimony and sulphur segregation in iron. Data from intergranular fracture experiments involving these same segregants is also summarized in an attempt to test the idea that segregation-induced embrittlement (or ductilization) can be understood in terms of the segregant's effect on 2γ int. Uncertainties in present data do not allow a convincing test, but it is not implausible that the deleterious effects of phosphorus, tin, and sulphur in iron can be understood in this way. The effect of carbon does not seem to be similarly understandable, although that may be due to the inappropriateness of the only available surface segregation data in that case, which are for a (001) surface rather than a general polycrystalline surface created by intergranular fracture.
Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy | Continue JAMA Internal Medicine HomeNew OnlineCurrent IssueFor Authors Podcast Publications JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry (1919-1959) JN Learning / CMESubscribeJobsInstitutions / LibrariansReprints & Permissions Terms of Use | Privacy Policy | Accessibility Statement 2023 American Medical Association. All Rights Reserved Search All JAMA JAMA Network Open JAMA Cardiology JAMA Dermatology JAMA Forum Archive JAMA Health Forum JAMA Internal Medicine JAMA Neurology JAMA Oncology JAMA Ophthalmology JAMA Otolaryngology–Head & Neck Surgery JAMA Pediatrics JAMA Psychiatry JAMA Surgery Archives of Neurology & Psychiatry Input Search Term Sign In Individual Sign In Sign inCreate an Account Access through your institution Sign In Purchase Options: Buy this article Rent this article Subscribe to the JAMA Internal Medicine journal
Zwei selbstorganisierte redoxaktive Monoschichten aus [Ru(NH3)5(NC5H4-4-CH2NHCO(CH2)10SH](PF6)2 sind die Grundlage eines Metall-Molekül-Metall-Kontakts, dessen Elektronentransporteigenschaften beschrieben werden (siehe Bild). Der Kontakt wird leitend, wenn die Elektrodenpotentiale an das formale Potential der Redoxzentren angepasst werden, und zeigt Dioden- und Transistor-artige Charakteristika ähnlich denen von Festkörpersystemen.
Stress intensity factor distributions at the edge of semi-circular and semi-elliptical surface cracks are obtained for cracks aligned perpendicular to the surface of a semi-infinite solid subject to remote shear parallel to the plane of the crack. Mixed mode conditions along the crack edge are characterized. Application to fatigue crack thresholds in mixed mode is discussed.
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available from the CCDC and typically includes 3D coordinates, cell parameters, space group, experimental conditions and quality measures.
