Publications

ADVERTISEMENT RETURN TO ISSUEPREVCommunicationNEXTStability of Carbon Nitride Materials at High Pressure and TemperatureAndrew J. Stevens, Takaaki Koga, Carl B. Agee, Michael J. Aziz, and Charles M. LieberView Author Information Department of Chemistry and Chemical Biology Division of Engineering and Applied Sciences Department of Earth and Planetary Sciences Harvard University, Cambridge, Massachusetts 02138Cite this: J. Am. Chem. Soc. 1996, 118, 44, 10900–10901Publication Date (Web):November 6, 1996Publication History Received22 July 1996Published online6 November 1996Published inissue 1 January 1996https://pubs.acs.org/doi/10.1021/ja9625182https://doi.org/10.1021/ja9625182rapid-communicationACS PublicationsCopyright © 1996 American Chemical SocietyRequest reuse permissionsArticle Views820Altmetric-Citations47LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose SUBJECTS:Carbon,Inorganic carbon compounds,Nitrogen,Organic reactions,Precursors Get e-Alerts

Abstract Background: Adolescent diet may be etiologically relevant for later risk of colorectal adenoma (CRA), a precursor of colorectal cancer. Objective: To examine associations between adolescent dietary patterns (derived using factor analysis) and risk of CRA in middle adulthood. Design: We analyzed data from 17,221 women participating in the Nurses' Health Study II, who had completed a validated high school (HS) food frequency questionnaire in 1998 when they were 34-51 years old, and had subsequently undergone at least one lower bowel endoscopy. Results: Between 1998 and 2007, 1,299 women were diagnosed with at least one CRA. In multivariable models adjusted for adult dietary patterns, a higher “prudent” pattern during HS, characterized by high consumption of vegetables, fruit, and fish was associated with a statistically significantly lower risk of rectal (odds ratio (OR) highest versus lowest quintile, 0.45, 95% CI 0.27-0.75, p-trend=0.005), but not colon adenomas. A higher “Western” pattern during HS, characterized by high consumption of desserts and sweets, snack foods, and red and processed meat, was significantly associated with rectal (OR 1.78, 95% CI 1.12-2.85, p-trend=0.005) and advanced (OR 1.58, 95% CI 1.07-2.33, p-trend=0.08), but not associated with colon or non-advanced adenomas. Conclusions: This study suggests that overall eating patterns during high school may influence later risk of rectal and advanced adenoma, independent of adult diet. Our results support the hypothesis that diet during early life may influence colorectal carcinogenesis. Citation Format: Katherina Nimptsch, Vasanti S. Malik, Teresa Fung, Tobias Pischon, Frank B. Hu, Walter C. Willett, Charles S. Fuchs, Shuji Ogino, Andrew T. Chan, Edward L. Giovannucci, Kana Wu. Dietary patterns during high school and risk of colorectal adenoma in a cohort of middle-aged women. [abstract]. In: Proceedings of the Twelfth Annual AACR International Conference on Frontiers in Cancer Prevention Research; 2013 Oct 27-30; National Harbor, MD. Philadelphia (PA): AACR; Can Prev Res 2013;6(11 Suppl): Abstract nr B03.

A mechanism-based theory of strain gradient plasticity (MSG) is proposed based on a multiscale framework linking the microscale notion of statistically stored and geometrically necessary dislocations to the mesoscale notion of plastic strain and strain gradient. This theory is motivated by our recent analysis of indentation experiments which strongly suggest a linear dependence of the square of plastic flow stress on strain gradient. While such linear dependence is predicted by the Taylor hardening model relating the flow stress to dislocation density, existing theories of strain gradient plasticity have failed to explain such behavior. We believe that a mesoscale theory of plasticity should not only be based on stress–strain behavior obtained from macroscopic mechanical tests, but should also draw information from micromechanical, gradient-dominant tests such as micro-indentation or nano-indentation. According to this viewpoint, we explore an alternative formulation of strain gradient plasticity in which the Taylor model is adopted as a founding principle. We distinguish the microscale at which dislocation interaction is considered from the mesoscale at which the plasticity theory is formulated. On the microscale, we assume that higher order stresses do not exist, that the square of flow stress increases linearly with the density of geometrically necessary dislocations, strictly following the Taylor model, and that the plastic flow retains the associative structure of conventional plasticity. On the mesoscale, the constitutive equations are constructed by averaging microscale plasticity laws over a representative cell. An expression for the effective strain gradient is obtained by considering models of geometrically necessary dislocations associated with bending, torsion and 2-D axisymmetric void growth. The new theory differs from all existing phenomenological theories in its mechanism-based guiding principles, although the mathematical structure is quite similar to the theory proposed by Fleck and Hutchinson. A detailed analysis of the new theory is presented in Part II of this paper.

The degree of unsaturation was a major determinant of the architecture of lipid metabolic network. Lipid clusters that strongly predicted CVD risk, such as the HPC cluster, warrant further functional investigations.

India has the second largest number of people with diabetes in the world following China. Evidence indicates that consumption of whole grains can reduce the risk of type 2 diabetes. This article describes the study design and methods of a trial in progress evaluating the effects of substituting whole grain brown rice for polished (refined) white rice on biomarkers of diabetes risk (glucose metabolism, dyslipidemia, inflammation). This is a randomized controlled clinical trial with a crossover design conducted in Chennai, India among overweight but otherwise healthy volunteers aged 25-65 y with a body mass index ≥23 kg/m(2) and habitual rice consumption ≥200 g/day. The feasibility and cultural appropriateness of this type of intervention in the local environment will also be examined. If the intervention is efficacious, the findings can be incorporated into national-level policies which could include the provision of brown rice as an option or replacement for white rice in government institutions and food programs. This relatively simple dietary intervention has the potential to substantially diminish the burden of diabetes in Asia and elsewhere.

No abstract is provided for this article.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTImmobilization of synthetically useful enzymes by condensation polymerizationAlfred Pollak, Richard L. Baughn, Orn Adalsteinsson, and George M. WhitesidesCite this: J. Am. Chem. Soc. 1978, 100, 1, 302–304Publication Date (Print):January 1, 1978Publication History Published online1 May 2002Published inissue 1 January 1978https://pubs.acs.org/doi/10.1021/ja00469a062https://doi.org/10.1021/ja00469a062research-articleACS PublicationsRequest reuse permissionsArticle Views138Altmetric-Citations20LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InRedditEmail Other access optionsGet e-Alertsclose Get e-Alerts

Summary Objective Low‐grade chronic inflammation is associated with risk for type 2 diabetes. We investigated the associations between inflammatory factors and glycaemic status in a middle‐aged and older Chinese population. Design A population‐based cross‐sectional study of 3289 residents aged 50–70 years from Beijing and Shanghai. Measurements C‐reactive protein (CRP), interleukin‐6 (IL‐6) and soluble tumour necrosis factor α‐receptor two (sTNFR2) were assayed. Results Comparing the highest with the lowest quartile of CRP, the odds ratio (OR) of diabetes was significantly higher in women [3·66 (95% CI 2·23–6·03)] than in men [1·51 (0·95–2·41)] ( P for interaction = 0·004), while the increased OR for impaired fasting glucose (IFG) was only observed in women [OR 2·03 (1·44–2·84)] ( P for interaction = 0·022), after adjustment for age, geographic location, education, lifestyle factors, family history of diabetes, and use of antibiotics, aspirin and lipid‐lowering drugs. The multiple‐adjusted OR of IL‐6 for diabetes was also higher in women [2·95 (1·78–4·90)] than in men [2·23 (1·39–3·59)] ( P for interaction = 0·045). sTNFR2 was not associated with diabetes but inversely associated with IFG in men [OR 0·59 (0·41–0·85)] and women [OR 0·78 (0·56–1·09)] ( P for interaction = 0·13). In addition, CRP was significantly associated with increased HbA 1c in both genders within euglycaemia after multiple adjustments. Conclusions Inflammatory markers are closely associated with diabetes and IFG in Chinese people. These associations appear to be stronger in women than in men. Furthermore, plasma CRP is positively associated with HbA 1c even in euglycaemic individuals.

This paper surveys the variables controlling the lattice structure and charge in macroscopic Coulombic crystals made from electrically charged, millimeter-sized polymer objects (spheres, cubes, and cylinders). Mechanical agitation of these objects inside planar, bounded containers caused them to charge electrically through contact electrification, and to self-assemble. The processes of electrification and self-assembly, and the characteristics of the assemblies, depended on the type of motion used for agitation, on the type of materials used for the objects and the dish, on the size and shape of the objects and the dish, and on the number of objects. Each of the three different materials in the system (of the dish and of the two types of spheres) influenced the electrification. Three classes of structures formed by self-assembly, depending on the experimental conditions: two-dimensional lattices, one-dimensional chains, and zero-dimensional 'rosettes'. The lattices were characterized by their structure (disordered, square, rhombic, or hexagonal) and by the electrical charges of individual objects; the whole lattices were approximately electrically neutral. The lattices observed in this study were qualitatively different from ionic crystals; the charge of objects had practically continuous values which changed during agitation and self-assembly, and depended on experimental conditions which included the lattice structure itself. The relationship between charge and structure led to the coexistence of regions with different lattice structures within the same assembly, and to transformations between different lattice structures during agitation.

Rationale Lung function measures are heritable traits that predict population morbidity and mortality and are essential for the diagnosis of chronic obstructive pulmonary disease (COPD). Variations in many genes have been reported to affect these traits, but attempts at replication have provided conflicting results. Recently, we undertook a meta-analysis of Genome Wide Association Study (GWAS) results for lung function measures in 20,288 individuals from the general population (the SpiroMeta consortium). Objectives To comprehensively analyse previously reported genetic associations with lung function measures, and to investigate whether single nucleotide polymorphisms (SNPs) in these genomic regions are associated with lung function in a large population sample. Methods We analysed association for SNPs tagging 130 genes and 48 intergenic regions (+/−10 kb), after conducting a systematic review of the literature in the PubMed database for genetic association studies reporting lung function associations. Results The analysis included 16,936 genotyped and imputed SNPs. No loci showed overall significant association for FEV1 or FEV1/FVC traits using a carefully defined significance threshold of 1.3×10−5. The most significant loci associated with FEV1 include SNPs tagging MACROD2 (P = 6.81×10−5), CNTN5 (P = 4.37×10−4), and TRPV4 (P = 1.58×10−3). Among ever-smokers, SERPINA1 showed the most significant association with FEV1 (P = 8.41×10−5), followed by PDE4D (P = 1.22×10−4). The strongest association with FEV1/FVC ratio was observed with ABCC1 (P = 4.38×10−4), and ESR1 (P = 5.42×10−4) among ever-smokers. Conclusions Polymorphisms spanning previously associated lung function genes did not show strong evidence for association with lung function measures in the SpiroMeta consortium population. Common SERPINA1 polymorphisms may affect FEV1 among smokers in the general population.