6,332 publications from this institution
A general criterion for testing a mesh with topologically similar repeat units is given, and the analysis shows that only a few conventional element types and arrangements are, or can be made suitable for computations in the fully plastic range. Further, a new variational principle, which can easily and simply be incorporated into an existing finite element program, is presented. This allows accurate computations to be made even for element designs that would not normally be suitable. Numerical results are given for three plane strain problems, namely pure bending of a beam, a thick-walled tube under pressure, and a deep double edge cracked tensile specimen. The effects of various element designs and of the new variational procedure are illustrated. Elastic-plastic computation at finite strain are discussed.
The preclinical evidence supports the anti-neuroinflammatory potential of olive oil and its phenolic compounds, though the variability in experimental design, compound characterization, and outcome measures limits translational interpretation. While isolated compounds demonstrated more robust effects than whole oil, high doses and lack of pharmacokinetic data raise questions about clinical relevance. Future research should address these limitations and evaluate the neuroimmune effects of olive oil-derived compounds in human studies.
Abstract Die Komplexe (I) werden durch Reaktion von Neophyl‐Li (aus Dineophyl‐Hg und Li) mit tetramerem Jodo‐tributylphosphin‐Metall(I) in Äther bei ‐78°C dargestellt.
The question motivating the present study is whether metal sandwich plates with sufficiently strong cores are able to sustain substantially larger blast loads than monolithic solid plates of the same material and total mass. Circular plates clamped at their edges are considered under blast loads large enough to produce substantial deflections. The material is elastic–perfectly plastic. Material strain-rate dependence and fracture are neglected. A dynamic finite element formulation for elastic–plastic solids is employed to analyze the plate response. Uniformly distributed blast impulses are considered. As a basis for comparison, complete results are obtained for solid plates for both zero-period and finite-period impulses. Similar computations are carried out for a set of sandwich plates having tetragonal truss cores. The potential for superior strength and energy absorbing capacity of the sandwich plates is demonstrated compared with solid plates having the same mass. The importance of both the strength and energy absorbing capacity of the core are highlighted for superior blast resistance. Proposals for further research are made.
Pulsed laser deposition (PLD) has been used to prepare tetragonal Sr1−xNdxCuO2 thin films that have the parent structure of the high Tc copper oxide superconductors. Low-temperature deposition using a single source target has been shown to kinetically trap c-axis oriented, infinite layer Sr1−xNdxCuO2 materials on 〈100〉SrTiO3 substrates. In addition, electrical measurements indicate that neodymium substitution drives the system from an insulating to a weakly metallic state.
Type 2 diabetes is a global public health crisis that threatens the economies of all nations, particularly developing countries. Fueled by rapid urbanization, nutrition transition, and increasingly sedentary lifestyles, the epidemic has grown in parallel with the worldwide rise in obesity. Asia's large population and rapid economic development have made it an epicenter of the epidemic. Asian populations tend to develop diabetes at younger ages and lower BMI levels than Caucasians. Several factors contribute to accelerated diabetes epidemic in Asians, including the “normal-weight metabolically obese” phenotype; high prevalence of smoking and heavy alcohol use; high intake of refined carbohydrates (e.g., white rice); and dramatically decreased physical activity levels. Poor nutrition in utero and in early life combined with overnutrition in later life may also play a role in Asia's diabetes epidemic. Recent advances in genome-wide association studies have contributed substantially to our understanding of diabetes pathophysiology, but currently identified genetic loci are insufficient to explain ethnic differences in diabetes risk. Nonetheless, interactions between Westernized diet and lifestyle and genetic background may accelerate the growth of diabetes in the context of rapid nutrition transition. Epidemiologic studies and randomized clinical trials show that type 2 diabetes is largely preventable through diet and lifestyle modifications. Translating these findings into practice, however, requires fundamental changes in public policies, the food and built environments, and health systems. To curb the escalating diabetes epidemic, primary prevention through promotion of a healthy diet and lifestyle should be a global public policy priority.
