Zidovudine in Patients with HIV Infection

Letters1 February 1996Zidovudine in Patients with HIV InfectionJohn P.A. Ioannidis, MD, Joseph Lau, MD, and Henry S. Sacks, PhD, MDJohn P.A. Ioannidis, MDNew England Medical Center; Boston, MA 02111Mount Sinai Medical Center; New York, NY 10029, Joseph Lau, MDNew England Medical Center; Boston, MA 02111Mount Sinai Medical Center; New York, NY 10029, and Henry S. Sacks, PhD, MDNew England Medical Center; Boston, MA 02111Mount Sinai Medical Center; New York, NY 10029Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-124-3-199602010-00025 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:The risk ratio reported by Bucher and Griffith for progression to AIDS or death in long-term trials is identical to that which we obtained in our paper [1] (0.96 [CI, 0.81 to 1.13]; 0.88 [CI, 0.73 to 1.08]) if deaths not related to HIV infection are excluded. We believe, however, that their subgroup analysis is not sufficiently robust. Despite further stratification according to CD4 count, studies were pooled regardless of the presence or absence of symptoms (an important covariate), and no meta-regression was done. Overall, we claimed no important long-term benefit from early zidovudine treatment for any subgroup ...References1. Ioannidis JP, Cappalleri JC, Lau J, Skolnik PR, Melville B, Chalmers TC, et al. Early or deferred zidovudine therapy in HIV-infected patients with an AIDS-defining illness. A meta-analysis. Ann Intern Med. 1995; 122:856-66. Google Scholar2. Pocock SJ. Clinical Trials. A Practical Approach. New York: J Wiley; 1983. Google Scholar Author, Article, and Disclosure InformationAffiliations: New England Medical Center; Boston, MA 02111Mount Sinai Medical Center; New York, NY 10029 PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byPredictors and Impact of Patients Lost to Follow-Up in a Long-Term Randomized Trial of Immediate Versus Deferred Antiretroviral Treatment 1 February 1996Volume 124, Issue 3Page: 372-373KeywordsAIDSClinical trialsHIV infectionsRegression analysisRisk managementRisk ratio Issue Published: 1 February 1996 Copyright & PermissionsCopyright © 1996 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...