Aim: To delineate the association of end-stage renal disease (ESRD) and Wnt-proteins including the agonist R-spondin-1, the transducer β-catenin and the antagonists DKK1 and sclerostin. Materials & methods: Serum Wnt-pathway proteins levels were measured by ELISA in 60 ESRD patients and 30 normal controls. Results: DKK1 and sclerostin were significantly higher in ESRD than in controls, and β-catenin and the catenin + R-spondin-1/DKK1 + sclerostin ratio, reflecting the ratio of agonist and transducer on antagonists (AT/ANTA), were significantly lower in ESRD. Estimated glomerular filtration rate was significantly associated with DKK1 and sclerostin (inversely), β-catenin (positively) and the AT/ANTA ratio (r = 0.468, p < 0.001). Conclusion: Wnt/β-catenin pathway proteins show significant alterations in ESRD, indicating significantly increased levels of antagonists.
Kaitlin J. Basham, Stephanie Rodriguez, Adina F. Turcu, Antonio M. Lerario, Catriona Y Logan, Madeline R. Rysztak, Celso E. Gómez-Sánchez, David T. Breault, Bon‐Kyoung Koo, Hans Clevers, Roeland Nusse, Pierre Val, Gary D. Hammer, Kaitlin J. Basham, Stephanie Rodriguez, Adina F. Turcu, Antonio M. Lerario, Catriona Y Logan, Madeline R. Rysztak, Celso E. Gómez-Sánchez, David T. Breault, Bon‐Kyoung Koo, Hans Clevers,
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