Williams_et_al_extended_data

These extended data documents relate to the manuscript titled " Genome-wide association study of susceptibility to hospitalised respiratory infections", which has been submitted to Wellcome Open Research, and include the following files: · Supplementary materials and methods · Supplementary figures · Table S1: ICD-10 codes used to define the hospitalised respiratory infection phenotype. · Table S2: ICD-9 codes used to define the hospitalised respiratory infection phenotype in CHS and Partners Biobank. · Table S3: Summary statistics for the 56 sentinel variants from the discovery GWAS in UK Biobank. · Table S4: Availability of the 40 sentinel variants in the 11 follow-up cohorts. · Table S5: Results of the inverse variance-weighted fixed effects meta-analysis. · Table S6: Fine-mapping of the 56 association signals. · Table S7: Functional annotation of variants in the 95% credible sets. · Table S8: Association between variants in the 95% credible sets and gene expression across 48 tissues from GTEx (v7). · Table S9: Association between variants in the 95% credible sets and gene expression across three major human immune cell types from BLUEPRINT. · Table S10: Association between variants in the 95% credible sets and gene expression (cis-eQTLs) from eQTLGen. · Table S11: Colocalisation results from PICCOLO. · Table S12: Look-up of the sentinel variants in the 56 association signals in existing GWAS. · Table S13: Look-up of the sentinel variants in the 56 association signals in existing GWAS. · Table S14: Look-up of the sentinel variants in the 56 association signals in the COVID-19 Host Genetics Initiative meta-analysis results. Main materials and methods can be found in the main manuscript text.