What Happens When Underperforming Big Ideas in Research Become Entrenched?

Michael J. Joyner; Nigel Paneth; John P A Ioannidis

doi:10.1001/jama.2016.11076

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What Happens When Underperforming Big Ideas in Research Become Entrenched?

Article 2016 en

Abstract

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In this Viewpoint, John Ioannidis and colleagues review how rarely gene therapy and genomic medicine have led to breakthroughs for patients and call on the NIH to defund preclinical research that fails to deliver on its initial promise.

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