Recent studies in mice have revealed a role for the MyD88-like adapter, TIRAP/Mal, in both Toll-like receptor (TLR)-4 and TLR-2 signaling to NF-κB, but not in the “MyD88-independent” pathway to IRF-3 activated by TLR-4. The implications of these studies will be discussed.
Sybille Landwehr-Kenzel, Sandra Santos‐Sierra, Sachin D. Deshmukh, Inga Moeller, Bilge Ergin, Katherine A. Fitzgerald, Egil Lien, Akira Shizuo, Douglas T. Golenbock, Philipp Henneke
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