To the Editor As ever more critical care trials fail to demonstrate a mortality effect,1,2 we believe that randomized trials can be made more efficient and informative by the careful choice of a disease-oriented end point rather than mortality.
Kuniaki Takahashi, Patrick W. Serruys, Norihiro Kogame, Paweł Buszman, Philipp Lurz, Gillian A.J. Jessurun, Karel T. Koch, Roland P.T. Troquay, Bas Hamer, Ton Oude Ophuis, Krzysztof Milewski, Sjoerd H. Hofma, Joanna J. Wykrzykowska, Yoshinobu Onuma, Robbert J. de Winter, William Wijns
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