There are conflicting data regarding the effects of vigorous physical activity (PA) and cardiovascular disease risk factors. Representative samples of adults aged 20–35 from four northern California cities were studied both cross-sectionally and longitudinally in order to examine the relationships between vigorous PA and selected physiological risk factors. A self-report measure of habitual vigorous PA was validated by pulse rate. There were relationships, in both crosssectional and longitudinal analyses between self-reported vigorous PA and
HDL
LDL
ratio, especially for women. Relationships in cross-sectional analyses only were found between PA and diastolic blood pressure, total cholesterol, HDL-cholesterol, triglycerides, and alveolar carbon monoxide. The results of the present study generally tend to confirm investigations of other samples.
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