Venous Thrombosis — The Interaction of Genes and Environment

Venous thrombosis is the obstruction of the circulation by clots that have been formed locally in the veins or have been released from a thrombus elsewhere. The usual sites of thrombus formation are the superficial and deep veins of the legs, but it also may occur in veins in the brain, retina, liver, and mesentery.An important question is why thrombosis develops in a given person at a specific site at a particular age and time. Probably the formation and growth of a thrombus are caused by local activation of the coagulation system, combined with a disturbance in the balance . . .