Variability of macrolide-resistant profile in <i>Mycobacterium avium</i> complex pulmonary disease
Antimicrobial Agents and Chemotherapy 68(11)
Article 2024 English
Authors
KF
Kiyoharu Fukushima
YM
Yuki Matsumoto
YA
Yuko Abe
Abstract
1 min read
This single-center retrospective study aimed to analyze the variability of macrolide resistance (MR) in 68 patients with Mycobacterium avium complex pulmonary disease. Among 25 patients treated without macrolides, 13 (52%) reverted to macrolide-susceptible (MS) profiles. Only one (2%) of 43 patients who continued macrolide treatment showed this change. We compared 30 MR isolates with recent specimens. Among them, seven shifted to MS (five attributed to clonally related strains; two resulting from reinfection or polyclonal infection).
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