We have identified a phenomenon occurring in the usage of proposed "specific" Mitogen-activated protein kinase (MAPK) inhibitors. We found that especially inhibitors of p38 potentiate the activation of other MAPKs in various cell types. This finding will have tremendous impact on the interpretation of all former studies using MAPK inhibitors.
Endre Kiss‐Toth, Stephanie M. Bagstaff, Hye Youn Sung, Veronika Jozsa, Clare Dempsey, Jim Caunt, Kevin M. Oxley, David Wyllie, Tímea Polgár, Mary T. Harte, Luke O'neill, Eva E. Qwarnström, Steven Dower
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