Unveiling the tumor immune microenvironment of organ-specific melanoma metastatic sites

Jordan W. Conway; Robert V. Rawson; Serigne Lo; Tasnia Ahmed; Ismael A. Vergara; Tuba N. Gide; Grace H. Attrill; Matteo S. Carlino; Robyn P.M. Saw; John F. Thompson; Andrew J. Spillane; Kerwin F. Shannon; Brindha Shivalingam; Alexander M. Menzies; James S. Wilmott; Georgina V. Long; Richard A Scolyer; Inês Pires da Silva

doi:10.1136/jitc-2022-004884

Abstract

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Liver and brain melanoma metastases have a significantly reduced immune infiltrate than lung, subcut and LN metastases, which may account for poorer prognosis and reduced immunotherapy response rates in patients with liver or brain metastases. Increased TIM-3 expression in liver metastases suggests TIM-3 inhibitor therapy as a potential therapeutic opportunity to improve patient outcomes.

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