Unique features associated with hepatic oxidative DNA damage and DNA methylation in non‐alcoholic fatty liver disease

Naoshi Nishida; Norihisa Yada; Satoru Hagiwara; Toshiharu Sakurai; Masayuki Kitano; Masatoshi Kudo

doi:10.1111/jgh.13318

Abstract

1 min read

Patients with high serum AFP and high degree of ballooning showed accumulation of oxidative DNA damage that could be a seed of DNA methylation responsible for hepatocarcinogenesis. These characteristics could be risk of HCC; such patients require urgent intervention such as lifestyle modification.

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