Turning the Pump Handle: Evolving Methods for Integrating the Evidence on Gene-Disease Association

Recent findings from genome-wide association studies have demonstrated their considerable potential for identify-ing genetic determinants of common diseases of public health significance such as cancer, heart disease, and diabetes (1), but they have also highlighted the continued importance of targeted genotyping to replicate genome-wide association findings (2).Approaches to the integration of evidence in human genome epidemiology have evolved rapidly in the last few years.The combination of results from