Tumor-Infiltrating Lymphocytes and Their Significance in Melanoma Prognosis

Tobias Schatton; Richard A Scolyer; John F. Thompson; Martín C. Mihm

doi:10.1007/978-1-62703-727-3_16

Abstract

1 min read

The role of the tumor-infiltrating lymphocyte (TIL) and its relationship to prognosis has been most extensively studied in malignant melanoma. The purpose of this chapter is to discuss in depth the immunobiology and molecular aspects of lymphocyte function in general and particularly TIL function in the context of antimelanoma immunity. Emphasis is placed upon the role of these inflammatory mediators in the enhancement and impairment of progression of this often fatal human cancer. In addition, the analysis of TILs in melanoma and their direct relationship to prognosis as well as their effect on the positivity of the sentinel lymph node will be discussed. Furthermore, details of lymph node responses to metastatic melanomas and their prognostic significance will be clarified. Finally, the importance of TILs for the evaluation of therapeutic response and how TIL immunobiology could critically inform the design of novel melanoma immunotherapeutic protocols will be elucidated.

Related publications

Chapter in a book2016

Skin cancer: melanoma

John F. Thompson, Richard A Scolyer, Richard F. Kefford

Article2021

Desmoplastic melanoma: a review of its pathology and clinical behaviour, and of management recommendations in published guidelines

Michael Hughes, Gabrielle Williams, David Gyorki, John W. Kelly, Jonathan R. Stretch, Alexander H. R. Varey, Angela Hong, Richard A Scolyer, John F. Thompson

Article2019

Combined Low Densities of FoxP3+ and CD3+ Tumor-Infiltrating Lymphocytes Identify Stage II Colorectal Cancer at High Risk of Progression

Tommaso Cavalleri, Gianluca Basso, Giuseppe Celesti, Fabio Grizzi, Paola Bossi, Luana Greco, Calogero Pitrone, Emanuele Valtorta, Gianluca Mauri, Mauro Truini, Filippo Gustavo Dall’Olio, Giovanni Brandi, Andrea Sartore‐Bianchi, Luigi Ricciardiello, Valter Torri, Lorenza Rimassa, Salvatore Siena, Alberto Mantovani, Alberto Malesci, Luigi Laghi

Dataset

Dataset related to article "Combined low densities of FoxP3+ and CD3+ tumor-infiltrating lymphocytes identify stage II colorectal cancer at high risk of progression"

Tommaso Cavalleri, Paolo Bianchi, Gianluca Basso, Giuseppe Celesti, Fabio Grizzi, Paolo Bossi, Luana Greco, Calogero Pitrone, Emanuele Valtorta, Gianluca Mauri, Mauro Truini, Dall'Olio FG, Giovanni Brandi, Andrea Sartore‐Bianchi, Luigi Ricciardiello, Valter Torri, Lorenza Rimassa, Salvatore Siena, Alberto Mantovani, Alberto Malesci, Luigi Laghi, Alleanza Contro Il Cancro Colorectal Cancer Working Group

Dataset

Dataset related to article "Combined low densities of FoxP3+ and CD3+ tumor-infiltrating lymphocytes identify stage II colorectal cancer at high risk of progression"

Tumor-Infiltrating Lymphocytes and Their Significance in Melanoma Prognosis

Abstract

Discussion(0)

Related publications

Skin cancer: melanoma

Desmoplastic melanoma: a review of its pathology and clinical behaviour, and of management recommendations in published guidelines

Combined Low Densities of FoxP3+ and CD3+ Tumor-Infiltrating Lymphocytes Identify Stage II Colorectal Cancer at High Risk of Progression

Dataset related to article "Combined low densities of FoxP3+ and CD3+ tumor-infiltrating lymphocytes identify stage II colorectal cancer at high risk of progression"

Dataset related to article "Combined low densities of FoxP3+ and CD3+ tumor-infiltrating lymphocytes identify stage II colorectal cancer at high risk of progression"