Transplantation-Induced Ischemia-Reperfusion Injury Modulates Antigen Presentation by Donor Renal CD11c+F4/80+ Macrophages through IL-1R8 Regulation

Sistiana Aiello; Manuel Alfredo Podestà; Pamela Y. Rodriguez-Ordonez; Francesca Pezzuto; Nadia Azzollini; Samantha Solini; Camillo Carrara; Marta Todeschini; Federica Casiraghi; Marina Noris; Giuseppe Remuzzi; Ariela Benigni

doi:10.1681/asn.2019080778

Abstract

1 min read

IL-1R8 is a key regulator of donor renal macrophage functions after ischemia-reperfusion injury, crucial to guiding the phenotype and antigen-presenting role of these cells. It may therefore represent an intriguing pathway to explore with respect to modulating responses against autoantigens and alloantigens after kidney transplant.

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