Transgenic Mouse Models of Self-Tolerance and Autoreactivity by the Immune System

TOLERANCE AND FUNCTIONAL ACTIVITY OF MAJOR fll STOCOMPATIBILITY COMPLEX ANTIGEN-PRESENTING MOLECULES 498 Transgenic Class I Genes 498 Transgenic Class II I-Erx Genes 498 DEVELOPMENT OF T CELLS SHOWING BOTH MHC RECOGNITION AND SELF-TOLERANCE.... 500 Positive Selection for TCR Recognition of MHC and Determination of T Cell Fate 502 Negative Selection Against Thymocytes Recognizing Self-Antigens 507