Transcriptomics in Tumor and Normal Lung Tissues Identify Patients With Early-Stage Non–Small-Cell Lung Cancer With High Risk of Postsurgery Recurrence Who May Benefit From Adjuvant Therapies

Vladimir Lazar; Nicolas Girard; Eric Raymond; Jean-François Martini; Susan Galbraith; Jacques Raynaud; Catherine Bresson; Benjamin Solomon; Shai Magidi; Hovav Nechushtan; Amir Onn; Raanan Berger; Haiquan Chen; Amal Al‐Omari; Sadakatsu Ikeda; Ulrik Lassen; Marina Sekacheva; Enriqueta Felip; Josep Tabernero; Gerald Batist; Alan Spatz; C.S. Pramesh; Philippe Girard; Jean Yves Blay; Thierry Philip; Ioana Berindan‐Neagoe; Angel Porgador; Eitan Rubin; Razelle Kurzrock; Richard L. Schilsky

doi:10.1200/po.22.00072

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Jean Yves Blay

Transcriptomics in Tumor and Normal Lung Tissues Identify Patients With Early-Stage Non–Small-Cell Lung Cancer With High Risk of Postsurgery Recurrence Who May Benefit From Adjuvant Therapies

Article 2022 en

Authors

VL
Vladimir Lazar
NG
Nicolas Girard
ER
Eric Raymond

Abstract

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TNM stage, DDPP score, and immune competence status of normal lung are independent prognostic factors in multivariate analysis. Our findings open new avenues for prospective prognostic assessment and treatment assignment on the basis of transcriptomic profiling of tumor and normal lung tissue in patients with NSCLC.

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Transcriptomics in Tumor and Normal Lung Tissues Identify Patients With Early-Stage Non–Small-Cell Lung Cancer With High Risk of Postsurgery Recurrence Who May Benefit From Adjuvant Therapies

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