Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolism

Marcus Tan; Chelsea A. Isom; Yangzi Liu; David‐Alexandre Trégouët; Sara Lindström; Lu Wang; Erin N. Smith; William Gordon; Astrid van Hylckama Vlieg; Mariza De Andrade; Jennifer A. Brody; Jack Pattee; Jeffrey Haessler; Ben Brumpton; Daniel I. Chasman; Pierre Suchon; Ming‐Huei Chen; Constance Turman; Marine Germain; Kerri L. Wiggins; James MacDonald; Sigrid K. Brækkan; Sebastian M. Armasu; Nathan Pankratz; Rabecca D Jackson; Jonas B. Nielsen; Franco Giulianini; Marja Puurunen; Manal Ibrahim; Susan R. Heckbert; Theo K. Bammler; Kelly A. Frazer; Bryan M. McCauley; Kent D. Taylor; James S. Pankow; Alexander P. Reiner; Maiken E. Gabrielsen; Jean‐François Deleuze; Christopher J. O’Donnell; Jihye Kim; Barbara McKnight; Peter Kraft; J.-B. Hansen; Frits R. Rosendaal; John A. Heit; Bruce M. Psaty; Weihong Tang; Charles Kooperberg; Kristian Hveem; Paul M. Ridker; Pierre‐Emmanuel Morange; Andrew M. Johnson; Christopher Kabrhel; David‐Alexandre Trégouët; Nicholas H. Smith; Lang Wu; Dan Zhou; Eric R. Gamazon

doi:10.1016/j.ebiom.2024.105233

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Frits R. Rosendaal

Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolism

EBioMedicine 106: 105233-105233

Article 2024 English

Authors

MT
Marcus Tan
CI
Chelsea A. Isom
YL
Yangzi Liu

Abstract

1 min read

Two important questions regarding the genetics of pancreatic adenocarcinoma (PDAC) are 1. Which germline genetic variants influence the incidence of this cancer; and 2. Whether PDAC causally predisposes to associated non-malignant phenotypes, such as type 2 diabetes (T2D) and venous thromboembolism (VTE).

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Transcriptome-wide association study and Mendelian randomization in pancreatic cancer identifies susceptibility genes and causal relationships with type 2 diabetes and venous thromboembolism

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