Traceless chemical ligations from O-acyl serine sites
Article 2012 en
Authors
MK
Mirna El Khatib
ME
Mohamed Elagawany
FJ
Farukh Jabeen
Abstract
1 min read
Chemical ligation via O- to N-acyl transfer of O-acylated serine containing peptides affords serine containing native peptides via 8- and 11-membered cyclic transition states opening the door to a wide variety of potential applications to peptide elaboration. The feasibility of these traceless chemical ligations is feasible as supported by computation.
Aritra Pal, R. Kraetzner, Tim Gruene, Marcel Grapp, Kathrin Schreiber, Mads Grønborg, Henning Urlaub, Stefan Becker, Abdul R. Asif, Jutta Gärtner, In Memory: G.M. Sheldrick (1942–2025), Robert Steinfeld
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