TNF-receptor 1 ameliorates disease progression of Nemo-mediated hepatitis
Article 2011 de
Authors
AS
Anju Singh
FC
FJ Cubero
EB
Erawan Borkham‐Kamphorst
Abstract
1 min read
Hepatocyte-specific NEMO knockout mice (NemoΔhepa) show that the IκB kinase subunit NEMO/IKKγ is essential for activating NF-κB, which regulates cellular responses during inflammation, cell proliferation and apoptosis. In the present study we aimed to better characterise the protective pathways in death receptor-mediated hepatocyte apoptosis in NemoΔhepa animals. We thus established NemoΔhepaTRAIL-/-, NemoΔhepaTNFR1-/- and NemoΔhepaTRAIL-/-TNFR1-/- and analyzed its consequences on disease progression compared to NemoΔhepa animals.
Francisco Javier Cubero, Erawan Borkham‐Kamphorst, Yulia A. Nevzorova, Mark V. Boekschoten, Nikolaus Gaßler, Ralf Weiskirchen, Tom Luedde, Mathias Heikenwälder, Michael Müller, Christian Liedtke, Christian Trautwein
Kira Bettermann, Mihael Vucur, Johannes Haybaeck, Christiane Koppe, Jörn Janssen, Felix Heymann, Achim Weber, Ralf Weiskirchen, Christian Liedtke, Nikolaus Gaßler, Michael Müller, Rita De Vos, Monika Wolf, Yannick Boege, Gitta Maria Seleznik, Nicolas Zeller, Daniel Erny, Thomas J. Fuchs, Stefan Zoller, Stefano Cairo, Marie‐Annick Buendia, Marco Prinz, Akira Shizuo, Frank Tacke, Mathias Heikenwälder, Christian Trautwein, Tom Luedde
Discussion(0)
No comments yet. Be the first to comment.