The Unrecognized Prevalence of Primary Aldosteronism

Letters20 October 2020The Unrecognized Prevalence of Primary AldosteronismGeorgios P. Piaditis, MD, PhD, Grigorios Kaltsas, MD, PhD, Athina Markou, MD, PhD, and George P. Chrousos, MDGeorgios P. Piaditis, MD, PhDHenry Dunant Hospital Center, Athens, Greece. (G.P.P.)Search for more papers by this author, Grigorios Kaltsas, MD, PhDNational and Kapodistrian University of Athens, Athens, Greece (G.K., G.P.C.)Search for more papers by this author, Athina Markou, MD, PhDG. Gennimatas General Hospital, Athens, Greece (A.M.)Search for more papers by this author, and George P. Chrousos, MDNational and Kapodistrian University of Athens, Athens, Greece (G.K., G.P.C.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/L20-1096 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail TO THE EDITOR:Brown and colleagues (1) used urinary aldosterone excretion cutoffs of greater than 10 µg/24 h and greater than 12 µg/24 h to diagnose primary aldosteronism in hypertensive patients. They found adjusted prevalence rates of primary aldosteronism ranging from 16% to 22%. When a urinary aldosterone excretion cutoff of greater than 10 µg/24 h was used and the analysis was restricted to patients with suppressed plasma renin levels, these prevalence rates ranged from 27% to 58%. Of interest, when 289 normotensive participants were studied using the urinary aldosterone excretion cutoff of 12 µg/24 h, the adjusted prevalence of ...References1. Brown JM, Siddiqui M, Calhoun DA, et al. The unrecognized prevalence of primary aldosteronism. A cross-sectional study. Ann Intern Med. 2020;173:10-20. [PMID: 32449886]. doi:10.7326/M20-0065 LinkGoogle Scholar2. Piaditis G, Markou A, Papanastasiou L, et al. Progress in aldosteronism: a review of the prevalence of primary aldosteronism in pre-hypertension and hypertension. Eur J Endocrinol. 2015;172:R191-203. [PMID: 25538205] doi:10.1530/EJE-14-0537 CrossrefMedlineGoogle Scholar3. Markou A, Pappa T, Kaltsas G, et al. Evidence of primary aldosteronism in a predominantly female cohort of normotensive individuals: a very high odds ratio for progression into arterial hypertension. J Clin Endocrinol Metab. 2013;98:1409-16. [PMID: 23471976] doi:10.1210/jc.2012-3353 CrossrefMedlineGoogle Scholar4. Vaidya A, Mulatero P, Baudrand R, et al. The expanding spectrum of primary aldosteronism: implications for diagnosis, pathogenesis, and treatment. Endocr Rev. 2018;39:1057-88. [PMID: 30124805] doi:10.1210/er.2018-00139 CrossrefMedlineGoogle Scholar5. Markou A, Sertedaki A, Kaltsas G, et al. Stress-induced aldosterone hyper-secretion in a substantial subset of patients with essential hypertension. J Clin Endocrinol Metab. 2015;100:2857-64. [PMID: 25974737] doi:10.1210/jc.2015-1268 CrossrefMedlineGoogle Scholar Author, Article, and Disclosure InformationAffiliations: Henry Dunant Hospital Center, Athens, Greece. (G.P.P.)National and Kapodistrian University of Athens, Athens, Greece (G.K., G.P.C.)G. Gennimatas General Hospital, Athens, Greece (A.M.)Disclosures: Authors have disclosed no conflicts of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=L20-1096. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoThe Unrecognized Prevalence of Primary Aldosteronism Jenifer M. Brown , Mohammed Siddiqui , David A. Calhoun , Robert M. Carey , Paul N. Hopkins , Gordon H. Williams , and Anand Vaidya The Unrecognized Prevalence of Primary Aldosteronism Anand Vaidya , Jenifer M. Brown , Robert M. Carey , Mohammed Siddiqui , and Gordon H. Williams The Unrecognized Prevalence of Primary Aldosteronism R. Haridian Sosa Barrios , Miriam Menacho-Román , A.L. Mataix , and Fernando Liaño García The Unrecognized Prevalence of Primary Aldosteronism Stefan Pilz , Martin R. Grübler , Verena Theiler-Schwetz , Oliver Malle , and Christian Trummer Metrics 20 October 2020Volume 173, Issue 8Page: 681KeywordsAdrenocorticotropic hormoneAldosteroneBlood plasmaConflicts of interestDisclosureExcretionHypertensionMineralocorticoidsPopulation statisticsSurgery ePublished: 20 October 2020 Issue Published: 20 October 2020 Copyright & PermissionsCopyright © 2020 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...